RT Journal Article
T1 Pain and Cortisol in Patients with Fibromyalgia: Systematic Review and Meta-Analysis
A1 Úbeda D’Ocasar, Edurne
A1 Jiménez Díaz Benito, Victor
A1 Gallego Sendarrubias, Gracia María
A1 Valera Calero, Juan Antonio
A1 Vicario Merino, Ángel
A1 Hervás Pérez, Juan Pablo
AB This systematic review and meta-analysis sought to gain further insight into the relationship between cortisol reactivity and chronic widespread pain in patients with fibromyalgia. The studies selected were those conducted in adults with fibromyalgia that were random controlled, non-controlled or observational. Studies were excluded if they examined diseases other than fibromyalgia or if they did not report on pain or cortisol. Twelve studies met inclusion criteria. Data were extracted into tabular format using predefined data fields by two reviewers and assessed for accuracy by a third reviewer. The methodological quality of the studies was assessed using the PEDro scale. Data Synthesis: Of 263 studies identified, 12 were selected for our review and 10 were finally included as their methodological quality was good. In the meta-analysis, we calculated effect sizes of interventions on pain indicators and cortisol levels in patients with fibromyalgia. A small overall effect of all the interventions was observed on pain tolerance and pressure pain thresholds, yet this effect lacked significance (ES = 0.150; 95%CI 0.932–1.550; p > 0.05). Conclusions: While some effects of individual nonpharmacological therapeutic interventions were observed on both cortisol levels and measures of pain, our results suggest much further work is needed to elucidate the true relationship between chronic widespread pain and cortisol levels in patients with fibromyalgia.
PB Multidisciplinary Digital Publishing Institute (MDPI)
YR 2020
FD 2020-11-09
LK https://hdl.handle.net/20.500.14352/136536
UL https://hdl.handle.net/20.500.14352/136536
LA eng
NO Úbeda-D’ocasar E, Díaz-Benito VJ, Gallego-Sendarrubias GM, Valera-Calero JA, Vicario-Merino Á, Hervás-Pérez JP. Pain and cortisol in patients with fibromyalgia: Systematic review and meta-analysis. Diagnostics. 2020;10(11).
DS Docta Complutense
RD 21 may 2026