RT Journal Article
T1 Characterization of Heterogeneous Polysaccharides from the Aerial Parts of Clinopodium bolivianum (Benth.) with Neutralizing Activity Against HIV-1 Infection
A1 Hernández Benito, Estefanía Patricia
A1 Bermejo Benito, Paulina
A1 Beltrán Vicente, Manuela
A1 Alcami Pertejo, José
A1 Prieto, Alicia
A1 Guerra Guirao, José Antonio
A1 Bedoya Del Olmo, Luis Miguel
AB Medicinal plants are widely used in Bolivian folk medicine for the treatment of infectious diseases. We have selected one, Clinopodium bolivianum (Benth.) Kuntze, known as “Khoa”, to investigate its potential anti-HIV activity since, traditionally, it has been used to treat other viral infectious diseases. We have carried out an antiviral bioassay-guided fractionation of different extracts of the aerial parts of C. bolivianum. An antiviral crude polysaccharide was obtained, (SBAS), which is rich in glucose, galactose, mannose, arabinose, xylose, and rhamnose and only has traces of galacturonic acid. SBAS exhibited antiviral activity with a mechanism of action unrelated to the mannose–lectin DC-SIGN receptors but with a strong viral neutralization activity. In summary, a purified polysaccharide from C. bolivianum has been identified as the main compound responsible for its antiviral activity. SBAs proved to be a neutralizing agent with high antiviral capacity in vitro, so they could be part of new microbicide formulations to prevent HIV transmission.
PB MDPI
YR 2025
FD 2025-03-03
LK https://hdl.handle.net/20.500.14352/124891
UL https://hdl.handle.net/20.500.14352/124891
LA eng
NO Hernández E, Bermejo P, Abad MJ, Beltrán M, Alcamí J, Prieto A, Guerra JA, Bedoya LM. Characterization of Heterogeneous Polysaccharides from the Aerial Parts of Clinopodium bolivianum (Benth.) with Neutralizing Activity Against HIV-1 Infection. Polysaccharides 2025;6:18. https://doi.org/10.3390/polysaccharides6010018.
NO Instituto de Salud Carlos III  (España)
NO Centro de Investigación Biomédica en Red de Enfermedades Infecciosas (España)
DS Docta Complutense
RD 17 mar 2026