RT Journal Article
T1 Metabolomic study of plasma of patients with abdominal aortic aneurysm
A1 Rupérez, Francisco J.
A1 Ramos-Mozo, Priscila
A1 Teul, Joanna
A1 Martinez-Pinna, Roxana
A1 Garcia, Antonia
A1 Malet-Martino, Myriam
A1 Camafeita, Emilio
A1 Lopez, Juan Antonio
A1 Pastor Vargas, Carlos
A1 Egido, Jesús
A1 Balayssac, Stéphane
A1 Gilard, Véronique
A1 Barbas, Coral
A1 Martin-Ventura, Jose Luis
AB Abdominal aortic aneurysm (AAA) is an important health problem, both because of AAA rupture and death and because of increased cardiovascular mortality. Identification of new biomarkers of AAA may suggest novel pathological mechanisms and targets for new medical treatments to slow AAA progression. Metabolic changes in AAA patients were mainly related to carbohydrate and lipid metabolism and many of these changes can be associated with a situation of insulin resistance (which can be related to metabolic syndrome) together with altered amino acid metabolism. For the first time, metabolites that can be associated with differential metabolism by the gut microflora of AAA patients have also been found. Moreover, aminomalonic acid in plasma has been shown to be the metabolite with the biggest difference between patients suffering from large aneurysm (>5 cm) and controls.
PB Springer
SN 1618-2642
SN 1618-2650
YR 2012
FD 2012-04-29
LK https://hdl.handle.net/20.500.14352/107276
UL https://hdl.handle.net/20.500.14352/107276
LA eng
NO Rupérez FJ, Ramos-Mozo P, Teul J, Martinez-Pinna R, Garcia A, Malet-Martino M, Camafeita E, Lopez JA, Pastor-Vargas C, Egido J, Balayssac S, Gilard V, Barbas C, Martin-Ventura JL. Metabolomic study of plasma of patients with abdominal aortic aneurysm. Anal Bioanal Chem. 2012 Jun;403(6):1651-60. doi: 10.1007/s00216-012-5982-y. Epub 2012 Apr 29. PMID: 22543712.
DS Docta Complutense
RD 31 ago 2024