RT Journal Article
T1 Double click macrocyclization with Sondheimer diyne of aza-dipyrrins for B–Free bioorthogonal imaging
A1 Wu, Dan
A1 Durán Sampedro, Gonzalo
A1 Fitzgerald, Sheila
A1 Garre, Massimiliano
A1 O'Shea, Donal
AB Sequential azide/diyne cycloadditions proved highly effective for the macrocyclization of a bis-azido aza-dipyrrin. Macrocyclic aza-dipyrrin could be produced in 30 min at rt in water with changes in fluorescence intensity and lifetimes measurable upon reaction. Live cell microscopy showed that aza-dipyrrins were suitable for confocal and STED super-resolution imaging and a bioorthogonal response to macrocyclization could be detected in cellular compartments. These results will encourage a broader examination of the sensing and imaging uses of aza-dipyrrins.
PB Royal Society of Chemistry
SN 1359-7345
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/94999
UL https://hdl.handle.net/20.500.14352/94999
LA eng
NO Wu, Dan, et al. «Double Click Macrocyclization with Sondheimer Diyne of Aza-Dipyrrins for B–F ree Bioorthogonal Imaging». Chemical Communications, vol. 59, n.o 14, 2023, pp. 1951-54. https://doi.org/10.1039/D2CC06461H.
NO Science Foundation Ireland
NO European Commission
DS Docta Complutense
RD 10 abr 2025