RT Journal Article
T1 Early Appearance of Epicardial Adipose Tissue through Human Development
A1 Pérez De Miguelsanz, María Juliana
A1 Jiménez Ortega, Vanesa
A1 Cano Barquilla, María Pilar
A1 Garaulet, Marta
A1 Esquifino, Ana I.
A1 Varela Moreiras, Gregorio
A1 Fernández Mateos, María Del Pilar
AB Background: Epicardial adipose tissue (EAT) is a visceral fat depot with unique anatomic, biomolecular and genetic features. Due to its proximity to the coronary arteries and myocardium, dysfunctional EAT may contribute to the development and progression of cardiovascular and metabolic-related adiposity-based chronic diseases. The aim of this work was to describe, by morphological techniques, the early origin of EAT. Methods: EAT adipogenesis was studied in 41 embryos from 32 gestational days (GD) to 8 gestational weeks (GW) and in 23 fetuses until full term (from 9 to 36 GW).Results: This process comprises five stages. Stage 1 appears as mesenchyme at 33–35 GD. Stage 2 is characterized by angiogenesis at 42–45 GD. Stage 3 covers up to 34 GW with the appearance of small fibers in the extracellular matrix. Stage 4 is visible around the coronary arteries, as multilocular adipocytes in primitive fat lobules, and Stage 5 is present with unilocular adipocytes in the definitive fat lobules. EAT precursor tissue appears as early as the end of the first gestational month in the atrioventricular grooves. Unilocular adipocytes appear at the eighth gestational month.Conclusions: Due to its early origin, plasticity and clinical implications, factors such as maternal health and nutrition might influence EAT early development in consequence.
PB MPDI
SN 2072-6643
YR 2021
FD 2021-08-24
LK https://hdl.handle.net/20.500.14352/4828
UL https://hdl.handle.net/20.500.14352/4828
LA eng
NO Perez Miguelsanz, J., Jiménez Ortega, V., Cano Barquilla, M. P. et al. «Early Appearance of Epicardial Adipose Tissue through Human Development». Nutrients, vol. 13, n.o 9, agosto de 2021, p. 2906. DOI.org (Crossref), https://doi.org/10.3390/nu13092906.
NO Ministerio de Ciencia, Innovación y Universidades (España)/Fondo Europeo de Desarrollo Regional
NO Universidad Complutense de Madrid
NO Comunidad Autónoma de la Región de Murcia/Fundación Séneca
DS Docta Complutense
RD 20 abr 2025