RT Journal Article
T1 Molecular gates in mesoporous bioactive glasses for the treatment of bone tumors and infection
A1 Polo, Lorena
A1 Gómez Cerezo, María Natividad
A1 Vivancos, Jose Luis
A1 Sancenón, Félix
A1 Arcos Navarrete, Daniel
A1 Vallet Regí, María Dulce Nombre
A1 Martínez Máñez, Ramón
AB Silica mesoporous nanomaterials have been proved to have meaningful application in biotechnology and biomedicine. Particularly, mesoporous bioactive glasses are recently gaining importance thanks to their bone regenerative properties. Moreover, the mesoporous nature of these materials makes them suitable for drug delivery applications, opening new lines in the field of bone therapies. In this work, we have developed innovative nanodevices based on the implementation of adenosine triphosphate (ATP) and e-poly-l-lysine molecular gates using a mesoporous bioglass as an inorganic support. The systems have been previously proved to work properly with a fluorescence probe and subsequently with an antibiotic(levofloxacin) and an antitumoral drug(doxorubicin). The bioactivity of the prepared materials has also been tested, giving promising results. Finally, in vitro cell culture studies have been carried out; demonstrating that this gated devices can provide useful approaches for bone cancer and bone infection treatments.Statement of SignificanceMolecular-gated materials have recently been drawing attention due to their applications in fields as biomedicine  and molecular recognition. For the first time as we are aware, we report herein a new enzymatic responsive molecular-gated device consisting in a mesoporous bioactive glass support implemented with two different molecular gates. Both controlled drug delivery properties and apatite-like phase formation ability of the device have been demonstrated, getting promising results. This approach opens up the possibility of developing new stimuli-responsive tailored biomaterials for bone cancer and infection treatments as well as regenerative bone grafts.
PB Elsevier
SN 1742-7061
YR 2016
FD 2016-12-08
LK https://hdl.handle.net/20.500.14352/17583
UL https://hdl.handle.net/20.500.14352/17583
LA spa
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NO RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. H2020
NO Ministerio de Ciencia e Innovación (MICINN)
NO Generalitat Valenciana
NO CIBER-BBN
NO Universitat Politècnica de València
DS Docta Complutense
RD 5 may 2024