RT Journal Article
T1 Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease
A1 De Frutos Lucas, Jaisalmer
A1 Cuesta Prieto, Pablo
A1 Ramírez Toraño, Federico
A1 Nebreda Pérez, Alberto
A1 Cuadrado Soto, Esther
A1 Peral Suárez, África
A1 López Sanz, David
A1 Bruña Fernández, Ricardo
A1 Marcos-de Pedro, Silvia
A1 Delgado Losada, María Luisa
A1 López Sobaler, Ana María
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Barabash Bustelo, Ana
A1 Serrano Rodríguez, Juan Manuel
A1 Laws, Simon M.
A1 Marcos Dolado, Alberto
A1 López Sánchez, Ramón
A1 Brown, Belinda M.
A1 Maestu Unturbe, Fernando
AB BACKGROUND: Electrophysiological studies show that reductions in power within the alpha band are associated with the Alzheimer’s disease (AD) continuum. Physical activity (PA) is a protective factor that has proved to reduce AD risk and pathological brain burden. Previous research has confirmed that exercise increases power in the alpha range. However, little is known regarding whether other non-modifiable risk factors for AD, such as increased age or APOE ε4 carriage, alter the association between PA and power in the alpha band. METHODS: The relationship between PA and alpha band power was examined in a sample of 113 healthy adults using magnetoencephalography. Additionally, we explored whether ε4 carriage and age modulate this association. The correlations between alpha power and gray matter volumes and cognition were also investigated. RESULTS: We detected a parieto-occipital cluster in which PA positively correlated with alpha power. The association between PA and alpha power remained following stratification of the cohort by genotype. Younger and older adults were investigated separately, and only younger adults exhibited a positive relationship between PA and alpha power. Interestingly, when four groups were created based on age (younger-older adult) and APOE (E3/E3-E3/E4), only younger E3/E3 (least predicted risk) and older E3/E4 (greatest predicted risk) had associations between greater alpha power and higher PA. Among older E3/E4, greater alpha power in these regions was associated with improved memory and preserved brain structure. CONCLUSION: PA could protect against the slowing of brain activity that characterizes the AD continuum, where it is of benefit for all individuals, especially E3/E4 older adults.
PB BMC
YR 2020
FD 2020-08-27
LK https://hdl.handle.net/20.500.14352/102218
UL https://hdl.handle.net/20.500.14352/102218
LA eng
NO de Frutos-Lucas, J., Cuesta, P., Ramírez-Toraño, F., Nebreda, A., Cuadrado-Soto, E., Peral-Suárez, Á., ... & Maestú, F. (2020). Age and APOE genotype affect the relationship between objectively measured physical activity and power in the alpha band, a marker of brain disease. Alzheimer's Research & Therapy, 12(1), 1-12.
NO Ministerio de Economía y Competitividad (España)
NO NEUROCENTRO
NO Fundación La Caixa
DS Docta Complutense
RD 17 ago 2024