RT Journal Article
T1 Gene-environment interaction between an endocannabinoid system genetic polymorphism and cannabis use in first episode of psychosis
A1 Bioque, Miquel
A1 Mas, Sergi
A1 Costanzo, Maria Cristina
A1 Cabrera, Bibiana
A1 Lobo, Antonio
A1 González Pinto, Ana
A1 Rodríguez Toscano, Elisa
A1 Corripio, Iluminada
A1 Vieta, Eduard
A1 Baeza, Inmaculada
A1 Ibáñez, Ángela
A1 Gutiérrez Fraile, Miguel
A1 Cuesta, Manuel J.
A1 Mezquida, Gisela
A1 Lafuente, Amalia
A1 Bernardo, Miguel
AB Alterations of the endocannabinoid system (ECS) may play an important role in the development of schizophrenia and other psychotic disorders. Cannabis use is one of the environmental factors more repeatedly related to an increase the risk of developing a psychotic episode, while its use modifies the ECS normal function. In the present study we purposed to examine the gene by environment (GxE) interaction between 15 selected single nucleotide polymorphisms (SNPs) related to the ECS and cannabis use in a cohort of 321 patients with a first episode of psychosis (FEP) and 241 matched healthy controls. We found the fatty-acid amide hydrolase (FAAH) rs2295633 SNP genetic polymorphism was associated with a greater risk of presenting a FEP in subjects with relevant cannabis use, but not in subjects without a history of cannabis use. The probability of presenting a FEP was tenfold higher (OR: 10.69) in cannabis users who were homozygote carriers of the T allele of the FAAH rs2295633 SNP, compared to users of cannabis without this genotype. We also found that a higher a proportion of TT carriers of the FAAH rs2295633 SNP with a positive history of cannabis use was treated with high potency antipsychotic. This study has identified a GxE-environment interaction between a genetic polymorphism from the ECS and cannabis use involved in the risk of presenting a FEP. Although this preliminary data should be replicated with independent samples, our results highlight the importance of the pro-psychotic effects of exogenous cannabis use over the ECS in certain subjects.
PB Elsevier
YR 2019
FD 2019-04-05
LK https://hdl.handle.net/20.500.14352/133625
UL https://hdl.handle.net/20.500.14352/133625
LA eng
NO M. Bioque, S. Mas and M.C. Costanzo et al., Gene-environment interaction between an endocannabinoid system genetic polymorphism and cannabis use in first episode of psychosis, European Neuropsychopharmacology, https://doi.org/10.1016/j. euroneuro.2019.04.005
NO Ministerio de Economía y Competitividad (España)
NO Instituto de Salud Carlos III
NO European Commission
NO Centro de Investigación Biomédica en Red de salud Mental
NO Generalitat de Catalunya
DS Docta Complutense
RD 24 mar 2026