RT Journal Article
T1 The potential of CD38 protein as a target for autoimmune diseases
A1 Ye, Xiaochun
A1 Zhao, Yongxia
A1 Ma, Wanqing
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 López Torres, Bernardo
A1 Martínez Larrañaga, María Rosa
A1 Wang, Xu
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
AB Cluster of differentiation 38 (CD38) is a multifunctional cell surface protein involved in nicotinamide adenine dinucleotide (NAD+) homeostasis in types of cells and tissues, which can be found in many immune cells and non-immune cells. Previous studies have shown that CD38 plays an important role in regulating innate immunity. Recently, many studies have revealed the importance of CD38 in autoimmune diseases, such as rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), multiple sclerosis (MS), type 1 diabetes (T1D) and inflammatory bowel disease, among others. In this report, we will briefly discuss the complex immunological functions of CD38 and focus on recent advances in the role of CD38 in the development and pathogenesis of autoimmune diseases, as well as their potential as therapeutic targets for systemic diseases, intending to make a comprehensive understanding of CD38 and its promising therapeutic potential in these systemic diseases
PB Elsevier B.V.
SN 1568-9972
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/124837
UL https://hdl.handle.net/20.500.14352/124837
LA eng
NO Ye, X., Zhao, Y., Ma, W., Ares, I., Martínez, M., Lopez-Torres, B., Martínez-Larrañaga, M. R., Wang, X., Anadón, A., & Martínez, M. A. (2023). The potential of CD38 protein as a target for autoimmune diseases. Autoimmunity reviews, 22(4), 103289. https://doi.org/10.1016/j.autrev.2023.103289
DS Docta Complutense
RD 8 jun 2026