RT Journal Article
T1 Tuning dual-drug release from composite scaffolds for bone2 regeneration
A1 Paris, J.L.
A1 Román, M.
A1 Cabañas Criado, María Victoria
A1 Vallet Regí, María Dulce Nombre
A1 Manzano García, Miguel
AB This work presents the tuning of drug-loaded scaffolds for bone regeneration as dual-drug delivery systems. Two therapeutic substances, zoledronic acid (anti-osteoporotic drug) and ibuprofen (antiinflammatory drug) were successfully incorporated in a controlled mannerinto three dimensional designed porous scaffolds of apatite/agarose composite. A high-performance liquid chromatography method was optimized to separate and simultaneously quantify the two drugs released from the dualdrug codelivery system. The multifunctional porous scaffolds fabricated show a very rapid delivery of anti-inflammatory (interesting to reduce inflammation after implantation), whereas the antiosteoporotic drug showed sustained release behaviour (important to promote bone regeneration). Since ibuprofen release was faster than desired, this drug was encapsulated in chitosan spheres which were then incorporated into the scaffolds, obtaining a release profile suitable for clinical application. The results obtained open the possibility to simultaneously incorporate two or more drugs to an osseous implant in a controlled way improving it for bone healing application.
PB Elsevier
SN Planta Medica
YR 2015
FD 2015-05-30
LK https://hdl.handle.net/20.500.14352/24050
UL https://hdl.handle.net/20.500.14352/24050
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ageing Network of Excellence
DS Docta Complutense
RD 29 abr 2024