RT Journal Article
T1 Peripheral blood reduction of memory (CD29+, CD45RO+, and “Bright” CD2+ and LFA-1+) T lymphocytes in Papillon-Lefèvre syndrome
A1 Góngora, Rafael
A1 Corell, Alfredo
A1 Regueiro, Jose R
A1 Carasol, Miguel
A1 Rodríguez-Gallego, Carlos
A1 Timón, Marcos
A1 Paz Artal, Estela Natividad
A1 Allende Martínez, Luis Miguel
A1 Arnaiz Villena, Antonio
AB A Papillon-Lefèvre patient with characteristic chronic periodontal disease and palmoplantar keratoderma was studied over a 4-year period. An abnormal T-cell phenotype was steadily observed in peripheral blood; both low numbers of CD29+ and CD45RO+ cells and a low density surface expression of CD2 and LFA-1 molecules were found. T-cell activation through CD3, CD2 and ConA, PWM and IL-2 receptors was normal; however, there was impairment in the activation via CD28. CD2, LFA-1 and CD45 molecules were normal in charge and molecular weight. There was no tissue sequestering of T lymphocytes in periodontal lesions, but rather a relative T-cell reduction. It is suggested that an important decrease of the so-called "memory/hyperreactive" (CD45RO-positive) T cells does exist; therefore, hyperreactive T cells would not be available in sufficient numbers to leave the bloodstream through blood vessel endothelium, and the periodontium would be left without these important defenses and thus exposed to chronic infections. A disregulated factor affecting the transition from "naive" to "memory" T cells and the increase in certain surface molecules expression (i.e., CD2, LFA-1, CD29, and CD45RO) or the reversion from memory to naive T cells may be responsible for the disease pathogenesis. CD2 and LFA-1 molecule synthesis might be conjointly regulated on T lymphocytes.
PB Elsevier
SN 0198-8859
YR 1994
FD 1994-11-01
LK https://hdl.handle.net/20.500.14352/97810
UL https://hdl.handle.net/20.500.14352/97810
LA eng
NO Góngora R, Corell A, Regueiro JR, Carasol M, Rodríguez-Gallego C, Paz-Artal E, Timón M, Allende L, Arnaiz-Villena A. Peripheral blood reduction of memory (CD29+, CD45RO+, and "bright" CD2+ and LFA-1+) T lymphocytes in Papillon-Lefèvre syndrome. Hum Immunol. 1994 Nov;41(3):185-92. doi: 10.1016/0198-8859(94)90035-3. PMID: 7532641.
DS Docta Complutense
RD 12 abr 2025