RT Journal Article
T1 Efecto del tratamiento optimizado con insulina en la reactividad plaquetaria tras el alta de pacientes hiperglucémicos con síndrome coronario agudo
T2 Effect of an Optimized Treatment With Insulin on Platelet Reactivity After Discharge in Patients With an Acute Coronary Syndrome and Hyperglycemia
A1 Vivas Balcones, Luis David
A1 García Rubira, Juan Carlos
A1 Bernardo, Esther
A1 Angiolillo, Dominick J
A1 Martín, Patricia
A1 Calle Pascual, Alfonso Luis
A1 Núñez Gil, Iván
A1 Macaya Miguel, Carlos
A1 Fernández Ortiz, Antonio
AB Introduction and objectives: Intensive glucose control with insulin in patients with an acute coronary syndrome reduces platelet reactivity during hospitalization, compared to conventional control. However, the effect of strict, long-term glucose control on platelet reactivity in these patients remains uncertain.Methods: This is a prospective, randomized trial evaluating the effects of optimized glucose control (target glucose, 80-120mg/dL) with insulin, compared with conventional control (target glucose, <180 mg/dL), on platelet reactivity after hospital discharge in patients with an acute coronary syndrome and hyperglycemia. The primary endpoint was assessment of platelet aggregation after stimulation with adenosine diphosphate 20 μM at 12-month follow-up.Results: One hundred four patients were randomized to optimized management (n=53) or conventional management (n=51). There were no differences between groups in baseline characteristics or platelet function. After 12 months of follow-up, blood glucose levels were significantly lower in the optimized treatment group (104 vs 119 mg/dL; P<.001). However, platelet aggregation following adenosine diphosphate 20 μM stimulation showed no differences between the groups (54.2% [14.3%] vs 55.1% [18.3%] respectively; P=.81). There were no significant differences for other platelet function tests.Conclusions: Long-term optimized glucose control with insulin in patients with an acute coronary syndrome did not result in a reduction in platelet reactivity compared to conventional control.
PB Sociedad Española de Cardiología
SN 1885-5857
YR 2014
FD 2014-01-01
LK https://hdl.handle.net/20.500.14352/99927
UL https://hdl.handle.net/20.500.14352/99927
LA eng
NO Vivas D, García-Rubira JC, Bernardo E, Angiolillo DJ, Martín P, Calle A, et al. Effect of an optimized treatment with insulin on platelet reactivity after discharge in patients with an acute coronary syndrome and hyperglycemia. Rev Esp Cardiol (Engl Ed). 2014;67:22-7
NO Fundación Interhospitalaria para la Investigación Cardiovascular
DS Docta Complutense
RD 22 ago 2024