RT Journal Article
T1 Flexible metallic core–shell nanostructured electrodes for neural interfacing
A1 Rodilla González, Beatriz Loreto
A1 Arché-Nuñez, Ana
A1 Ruiz-Gómez, Sandra
A1 Domínguez-Bajo, Ana
A1 Fernández-González, Claudia
A1 Guillén-Colomer, Clara
A1 González-Mayorga, Ankor
A1 Rodríguez-Díez, Noelia
A1 Camarero, Julio
A1 Miranda, Rodolfo
A1 López-Dolado, Elisa
A1 Ocón, Pilar
A1 Serrano, María Concepción
A1 Pérez García, Lucas
A1 González, M. Teresa
AB Electrodes with nanostructured surface have emerged as promising low-impedance neural interfaces that can avoid the charge‐injection restrictions typically associated to microelectrodes. In this work, we propose a novel approximation, based on a two-step template assisted electrodeposition technique, to obtain flexible nanostructured electrodes coated with core–shell Ni–Au vertical nanowires. These nanowires benefit from biocompatibility of the Au shell exposed to the environment and the mechanical properties of Ni that allow for nanowires longer and more homogeneous in length than their only-Au counterparts. The nanostructured electrodes show impedance values, measured by electrochemical impedance spectroscopy (EIS), at least 9 times lower than those of flat reference electrodes. This ratio is in good accordance with the increased effective surface area determinedboth from SEM images and cyclic voltammetry measurements, evidencing that only Au is exposed to the medium. The observed EIS profile evolution of Ni–Au electrodes over 7 days were very close to those of Au electrodes and differently from Ni ones. Finally, the morphology, viability and neuronal differentiation of rat embryonic cortical cells cultured on Ni–Au NW electrodes were found to besimilar to those on control (glass) substrates and Au NW electrodes, accompanied by a lower glial cell differentiation. This positive in-vitro neural cell behavior encourages further investigation to explore the tissue responses that the implantation of these nanostructured electrodes might elicit in healthy (damaged) neural tissues in vivo, with special emphasis on eventual tissue encapsulation.
PB Springer Nature
YR 2024
FD 2024-02-14
LK https://hdl.handle.net/20.500.14352/101561
UL https://hdl.handle.net/20.500.14352/101561
LA eng
NO Rodilla, B.L., Arché-Núñez, A., Ruiz-Gómez, S. et al. Flexible metallic core–shell nanostructured electrodes for neural interfacing. Sci Rep 14, 3729 (2024).
NO Ministerio de Ciencia e Innovación (España)
NO Agencia Estatal de Investigación (España)
NO Comunidad de Madrid
NO Unión Europea. Horizonte 2020
NO Fondo Europeo de Desarrollo Regional (Unión Europea)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 21 ago 2024