%0 Journal Article
%A Anadón Navarro, Arturo Ramón
%A Gamboa, Felipe
%A Martínez Caballero, María Aranzazu
%A Castellano Santos, Víctor Jesús
%A Martínez Caballero, Marta
%A Ares Lombán, Irma
%A Ramos Alonso, Eva
%A Suárez, Frank H.
%A Martínez Larrañaga, María Rosa
%T Plasma disposition and tissue depletion of chlortetracycline in the food producing animals, chickens for fattening
%D 2012
%@ 0278-6915
%U https://hdl.handle.net/20.500.14352/97581
%X Chickens were used to investigate plasma disposition of chlortetracycline after single IV (15 mg/kg) and multiple oral administration (60 mg/kg, 5 days) and residue depletion of chlortetracycline after multiple oral doses (60 mg/kg, 5 days). Plasma and tissue samples were analyzed by HPLC. Mean elimination half-lives in plasma were 7.96 and 13.15 h after IV and multiple oral administration. Maximum plasma concentration was 4.33 lg/ml and the interval from oral administration until maximal concentration was 1.79 h. Oral bioavailability was 17.76%. After multiple oral dose, mean kidney, liver and muscle tissue concentrations of chlortetracycline + 4-epi-chlortetracycline of 835.3, 192.7, and 126.3 ug/kg, respectively, were measured 1 day after administration of the final dose of chlortetracycline. Chlortetracycline residues were detected in kidney and liver (205.4 and 81.7 ug/kg, respectively), but not in muscle, 3 days after the end of chlortetracycline treatment. The mean chlortetracycline + 4-epi-chlortetracycline concentrations were below LOQ at 3 and 5 days after cessation of medication in muscle and liver, respectively. A withdrawal time of 3 days was necessary to ensure that the chlortetracycline residues were less than the maximal residue limits (MRLs) established by the European Union (100, 300, and 600 ug/kg in muscle, liver, and kidney, respectively).
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