RT Journal Article
T1 Plasma disposition and tissue depletion of chlortetracycline in the food producing animals, chickens for fattening
A1 Anadón Navarro, Arturo Ramón
A1 Gamboa, Felipe
A1 Martínez Caballero, María Aranzazu
A1 Castellano Santos, Víctor Jesús
A1 Martínez Caballero, Marta
A1 Ares Lombán, Irma
A1 Ramos Alonso, Eva
A1 Suárez, Frank H.
A1 Martínez Larrañaga, María Rosa
AB Chickens were used to investigate plasma disposition of chlortetracycline after single IV (15 mg/kg) and multiple oral administration (60 mg/kg, 5 days) and residue depletion of chlortetracycline after multiple oral doses (60 mg/kg, 5 days). Plasma and tissue samples were analyzed by HPLC. Mean elimination half-lives in plasma were 7.96 and 13.15 h after IV and multiple oral administration. Maximum plasma concentration was 4.33 lg/ml and the interval from oral administration until maximal concentration was 1.79 h. Oral bioavailability was 17.76%. After multiple oral dose, mean kidney, liver and muscle tissue concentrations of chlortetracycline + 4-epi-chlortetracycline of 835.3, 192.7, and 126.3 ug/kg, respectively, were measured 1 day after administration of the final dose of chlortetracycline. Chlortetracycline residues were detected in kidney and liver (205.4 and 81.7 ug/kg, respectively), but not in muscle, 3 days after the end of chlortetracycline treatment. The mean chlortetracycline + 4-epi-chlortetracycline concentrations were below LOQ at 3 and 5 days after cessation of medication in muscle and liver, respectively. A withdrawal time of 3 days was necessary to ensure that the chlortetracycline residues were less than the maximal residue limits (MRLs) established by the European Union (100, 300, and 600 ug/kg in muscle, liver, and kidney, respectively).
PB Elsevier
SN 0278-6915
YR 2012
FD 2012
LK https://hdl.handle.net/20.500.14352/97581
UL https://hdl.handle.net/20.500.14352/97581
LA eng
NO Anadón A, Gamboa F, Martínez MA, Castellano V, Martínez M, Ares I, Ramos E, Suarez FH, Martínez-Larrañaga MR. Plasma disposition and tissue depletion of chlortetracycline in the food producing animals, chickens for fattening. Food Chem Toxicol. 2012 Aug;50(8):2714-21. doi: 10.1016/j.fct.2012.05.007. Epub 2012 May 14. PMID: 22595330.
NO Universidad Complutense de Madrid
NO Comunidad de Madrid
NO Ministerio de Educación y Ciencia (España)
DS Docta Complutense
RD 10 abr 2025