RT Journal Article
T1 Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study
A1 Rojas Lozano, María Del Pilar
A1 Hoz Montañana, María Rosa De
A1 Ramírez Sebastián, Ana Isabel
A1 Ferreras, Antonio
A1 García Martín, Elena Salobrar
A1 Muñóz Blanco, José L
A1 Urcelay Segura, José Luis
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, José Manuel
AB Background: To compare early visual changes in amyotrophic lateral sclerosis (ALS) patients with healthy controls in a baseline exploration, to follow-up the patients after 6 months, and to correlate these visual changes with neurological disability. Methods: All patients underwent a comprehensive neurological and ophthalmological examination. A linear mixed analysis and Bonferroni p-value correction were performed, testing four comparisons as follows: Control baseline vs. control follow-up, control baseline vs. ALS baseline, control follow-up vs. ALS follow-up, and ALS baseline vs. ALS follow-up. Results: The mean time from the diagnosis was 10.80 ± 5.5 months. The analysis of the optical coherence tomography (OCT) showed: (1) In ALS baseline vs. control baseline, a macular significantly increased thickness of the inner macular ring temporal and inferior areas; (2) in ALS follow-up vs. ALS baseline, a significant macular thinning in the inner and outer macular ring inferior areas; (3) in ALS follow-up vs. ALS baseline, a significant peripapillary retinal nerve fiber layer (pRNFL) thinning in the superior and inferior quadrants; and (4) ALS patients showed a moderate correlation between some OCT pRNFL parameters and Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R) score. Conclusion: The OCT showed retinal changes in patients with motoneuron disease and could serve as a complementary tool for studying ALS.
PB MDPI AG
SN 2076-3425
YR 2019
FD 2019-12
LK https://hdl.handle.net/20.500.14352/5973
UL https://hdl.handle.net/20.500.14352/5973
LA eng
NO Rojas Lozano, P., Hoz Montañana, M. R., Ramírez Sebastián, A. I. et al. «Changes in Retinal OCT and Their Correlations with Neurological Disability in Early ALS Patients, a Follow-Up Study». Brain Sciences, vol. 9, n.o 12, noviembre de 2019, p. 337. DOI.org (Crossref), https://doi.org/10.3390/brainsci9120337.
NO Received: 14 October 2019 / Revised: 12 November 2019 / Accepted: 21 November 2019 / Published: 24 November 2019
DS Docta Complutense
RD 7 abr 2025