RT Journal Article
T1 The postnatal leptin surge supports immune cell function inrats
A1 Hunsche, Caroline
A1 Hernández, Oskarina
A1 Mela Rivas, Virginia
A1 Viveros, María Paz
A1 Fuente del Rey, Mónica de la
AB Background: Leptin plays an important role in the regulation of the immune response. There is a physiological surge of leptin in rodents during the neonatal period, which has mainly been studied in the context of brain development. However, little is known about the effects of this neonatal leptin surge on immunity. Therefore, we investigated whether blocking this leptin surge could affect several immune functions. Methods: Male and female rats were injected subcutaneously with 5 mg/Kg/day of rat pegylated super leptin antagonist during the neonatal period (PND5-9). On the peripubertal period, relevant functions as well as cytokine release by spleen leukocytes were studied in these animals. Results: The results showed that the animals significantly display an impaired anti-tumor NK activity and chemotactic and proliferation capacity of lymphocytes in response to mitogens. In addition, several cytokine concentrations, released under mitogen-stimulated conditions, were also altered. Conclusion: In conclusion, the neonatal leptin surge seems to be involved in the establishment of an adequate immune response and cytokine profile, which are crucial for the maintenance of a healthy life
PB Taylor and Francis
SN 0882-0139; Electronic: 1532-4311
YR 2021
FD 2021-06-14
LK https://hdl.handle.net/20.500.14352/8656
UL https://hdl.handle.net/20.500.14352/8656
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III (Madrid, España)/Fondo Europeo de Desarrollo Regional(FEDER)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 7 may 2024