TY  - JOUR
AU  - Morin, José A.
AU  - Cao García, Francisco Javier
AU  - Lázaro, José M.
AU  - Arias González, J. Ricardo
AU  - Valpuesta, José M.
AU  - Carrascosa, José L.
AU  - Salas, Margarita
AU  - Ibarra, Borja
PY  - 2015
DO  - 10.1093/nar/gkv204
SN  - 0305-1048
UR  - https://hdl.handle.net/20.500.14352/24122
T2  - Nucleic acids research
AB  - During DNA replication replicative polymerases move in discrete mechanical steps along the DNA template. To address how the chemical cycle is coupled to mechanical motion of the enzyme, here we use optical tweezers to study the translocation mechanism...
LA  - eng
M2  - 3643
PB  - Oxford University Press
KW  - Rapid conformational-changes
KW  - I klenow fragment
KW  - T7 RNA-polymerase
KW  - strand-displacement
KW  - Single-molecule
KW  - Nucleotide incorporation
KW  - Steady-state
KW  - Sulfolobus-solfataricus
KW  - Fingers subdomain
KW  - Crystal-structure
TI  - Mechano-chemical kinetics of DNA replication: identification of the translocation step of a replicative DNA polymerase
TY  - journal article
VL  - 43
ER  -