RT Journal Article
T1 Effects of Antifungal pretreatment on the susceptibility of Candida albicans to human leukocytes
A1 Mínguez Mínguez, Fernando A.
A1 Lima José Enrique, 
A1 García Esteban, María Teresa
A1 Prieto José, 
AB The aim of this work was to measure the susceptibility of Candida albicans pretreated for 2 or 6 h with fluconazole (Flu), ketoconazole (Ktz), amphotericin B (AmB) and 5-fluorocyto-sine (5-Fc) to the fungicidal action of human polymorphic leukocytes. The influence of pretreatment was measured by comparing the delay (in hours) and reduction (logio) in growth of pretreated cultures in the presence of leukocytes and serum with that of non-pretreated control cultures. Six-hour pretreat-ments with Flu, Ktz, AmB and 5-Fc led to growth delays of 1, 3, 3 and 3 h, respectively. No significant differences were found when pretreatment lasted only 2 h. With respect to a reduction in growth, this was larger when the preincubation was 6 h, mainly for 5-Fc and AmB. 5-Fc was seen to be the most effective, followed by Ktz, AmB and finally Flu. It may be concluded that antifungal pretreatment renders this yeast more susceptible to the action of leukocytes. The degree of susceptibility achieved is dependent on the antifungal agent employed.
PB Karger
SN 0009-3157
YR 1997
FD 1997
LK https://hdl.handle.net/20.500.14352/125376
UL https://hdl.handle.net/20.500.14352/125376
LA eng
NO Mínguez Mínguez, J.E. Lima, M.T. García, J. Prieto; Effects of Antifungal Pretreatment on the Susceptibility of Candida albicans to Human Leukocytes. Chemotherapy 1 May 1997; 43 (5): 346–351. https://doi.org/10.1159/000239588
DS Docta Complutense
RD 19 dic 2025