RT Journal Article
T1 Immune Tolerance in the Oral Mucosa
A1 Peláez Prestel, Héctor Fernando
A1 Sánchez Trincado López, José Luis
A1 Lafuente Duarte, Esther María
A1 Reche Gallardo, Pedro Antonio
AB The oral mucosa is a site of intense immune activity, where a large variety of immune cells meet to provide a first line of defense against pathogenic organisms. Interestingly, the oral mucosa is exposed to a plethora of antigens from food and commensal bacteria that must be tolerated. The mechanisms that enable this tolerance are not yet fully defined. Many works have focused on active immune mechanisms involving dendritic and regulatory T cells. However, epithelial cells also make a major contribution to tolerance by influencing both innate and adaptive immunity. Therefore, the tolerogenic mechanisms concurring in the oral mucosa are intertwined. Here, we review them systematically, paying special attention to the role of oral epithelial cells.
PB MDPI
SN 1422-0067
YR 2021
FD 2021-11-10
LK https://hdl.handle.net/20.500.14352/5059
UL https://hdl.handle.net/20.500.14352/5059
LA eng
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 1 may 2024