RT Journal Article
T1 Risk-score based strategy to minimize antibiotic exposure in children with sickle cell disease and fever
A1 Rincón López, Elena María
A1 Navarro Gómez, María Luisa
A1 Hernández-Sampelayo Matos, Teresa
A1 Saavedra Lozano, Jesús
A1 Cela De Julián, María Elena
A1 Vázquez López, Paula
A1 Garrido Colino, María Del Carmen
AB Severe bacterial infections (SBI) have become less frequent in children with sickle cell disease (SCD) in the last decades. However, because of their potential risk of SBI, they usually receive empirical therapy with broad-spectrum antibiotics when they develop fever and are hospitalized in many cases. We performed a prospective study including 79 SCD patients with fever [median age 4.1 (1.7-7.5) years, 78.5% males; 17 of the episodes were diagnosed with SBI and 4 of them were confirmed] and developed a risk score for the prediction of SBI. The optimal score included CRP > 3 mg/dl, IL-6 > 125 pg/ml and hypoxemia, with an AUC of 0.91 (0.83-0.96) for the prediction of confirmed SBI and 0.86 (0.77-0.93) for possible SBI. We classified the patients in 3 groups: low, intermediate and high risk of SBI. Our risk-score-based management proposal could help to safely minimize antibiotic treatments and hospital admissions in children with SCD at low risk of SBI.
PB Springer
SN 0300-8126
YR 2021
FD 2021-10-01
LK https://hdl.handle.net/20.500.14352/116174
UL https://hdl.handle.net/20.500.14352/116174
LA eng
NO Rincón-López, E. M., Navarro Gómez, M. L., Hernández-Sampelayo Matos, T., Aguilera-Alonso, D., Dueñas Moreno, E., Bellón Cano, J. M., Saavedra-Lozano, J., del Mar Santos Sebastián, M., García Morín, M., Beléndez Bieler, C., Lorente Romero, J., Cela de Julián, E., Santiago García, B., Hernanz Lobo, A., Bardón Cancho, E., Garrido Colino, C., Huerta Aragonés, J., Mata Fernández, C., Míguez Navarro, C., et al. (2022). Risk-score based strategy to minimize antibiotic exposure in children with sickle cell disease and fever. Infection, 50(2), 499-505. https://doi.org/10.1007/S15010-021-01702-W
NO European Society for Pediatric Infectious Diseases
DS Docta Complutense
RD 7 abr 2025