RT Journal Article
T1 Development of a method for assessing the accumulation and metabolization of antidepressant drugs in zebrafish (Danio rerio) eleutheroembryos
A1 Molina Fernández, Noemí
A1 Rainieri, Sandra
A1 Muñoz Olivas, Riansares
A1 Oro Carretero, Paloma de
A1 Sanz Landaluce, Jon
AB Antidepressant drugs are widely used for the treatment of common mental or other psychiatric disorders such as depression, which affect about 121 million people worldwide. This widespread use has contributed to the input of these pharmaceuticals and their metabolites into the environment. The aim of this work was to develop an analytical method to quantify the most widely used antidepressant drugs, selective serotonin reuptake inhibitors (SSRI), and their main metabolites in the environment. For this, a new and reliable miniaturized extraction method based on dispersive SPE cleanup procedure for extraction of SSRI followed by derivatization with n-heptafluorobutyrylimidazole, and detection by GC-MS was developed. The methodology, including a firstorder one-compartment model, was then applied to a bioconcentration study in zebrafish (Danio rerio) eleutheroembryos. The results showed low bioaccumulation of these compounds; however, a biotransformation evidence of the parent compounds into their metabolites was observed after 6 h of exposure. These results indicate the need to integrate metabolic transformation rates to fully model and understand the bioaccumulation patterns of SSRI and their metabolites.
PB Springer Nature
SN 1618-2642
YR 2021
FD 2021-06-30
LK https://hdl.handle.net/20.500.14352/6750
UL https://hdl.handle.net/20.500.14352/6750
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2021)
NO Ministerio de Economía y Competitividad (MINECO)
NO Comunidad de Madrid
NO Universidad Complutense de Madrid
NO Ministerio de Educación
DS Docta Complutense
RD 10 abr 2025