RT Journal Article
T1 Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules.
A1 Castillo, Rafael R.
A1 Lozano Borregón, Daniel
A1 Vallet Regí, María Dulce Nombre
AB The enormous versatility of mesoporous silica nanoparticles permits the creation of a large number of nanotherapeutic systems for the treatment of cancer and many other pathologies. In addition to the controlled release of small drugs, these materials allow a broad number of molecules of a very dièerent nature and sizes. In this review, we focus on biogenic species with therapeutic abilities (proteins, peptides, nucleic acids, and glycans), as well as how nanotechnology, in particular silica-based materials, can help in establishing new and more efficient routes for their administration. Indeed, since the applicability of those combinations of mesoporous silica with bio(macro)molecules goes beyond cancer treatment, we address a classification based on the type of therapeutic action.Likewise, as illustrative content, we highlight the most typical issues and problems found in the preparation of those hybrid nanotherapeutic materials.
PB MDPI
SN 1999-4923
YR 2020
FD 2020-05-07
LK https://hdl.handle.net/20.500.14352/6235
UL https://hdl.handle.net/20.500.14352/6235
LA eng
NO RESEARCHER ID L-2854-2014 (Rafael Castillo Romero)ORCID 0000-0003-1957-3098 (Rafael Castillo Romero)RESEARCHER ID B-5081-2017 (Daniel Lozano Borregón)ORCID 0000-0001-5902-9201 (Daniel Lozano Borregón)RESEARCHER ID M-3378-2014 (María Vallet Regí)ORCID 0000-0002-6104-4889 (María Vallet Regí)
NO Unión Europea. Horizonte 2020
DS Docta Complutense
RD 11 abr 2025