RT Journal Article
T1 Recent progress in adverse events of carboxylic acid non-steroidal anti-inflammatory drugs (CBA-NSAIDs) and their association with the metabolism: the consequences on mitochondrial dysfunction and oxidative stress, and prevention with natural plant extracts
A1 Liu, Yanan
A1 Yang, Chao
A1 Zhang, Jieying
A1 Ihsan, Awais
A1 Ares Lombán, Irma
A1 Martínez Caballero, Marta
A1 López Torres, Bernardo
A1 Martínez Larrañaga, María Rosa
A1 Wang, Xu
A1 Anadón Navarro, Arturo Ramón
A1 Martínez Caballero, María Aranzazu
AB Introduction: Carboxylic acid non-steroidal anti-inflammatory drugs (CBA-NSAIDs) are extensively used worldwide due to their antipyretic, analgesic, and anti-inflammatory effects. CBA-NSAIDs have reasonable margin of safety at therapeutic doses, and in the current climate, do not possess addiction potential like opioid drugs. Studies have revealed that various adverse events of CBA-NSAIDs are related mitochondrial dysfunction and oxidative stress.Areas covered: This review article summarizes adverse events induced by CBA-NSAIDs, mechanisms of mitochondrial damage, oxidative stress, and metabolic interactions. Meanwhile, this review discusses the treatment and prevention of CBA-NSAIDs damage by natural plant extracts based on antioxidant effects.Expert opinion: CBA-NSAIDs can induce reactive oxygen species (ROS) production, mediate DNA, protein and lipid damage, lead to imbalance of cell antioxidant status, change of mitochondrial membrane potential, activate oxidative stress signal pathway, thus leading to oxidative stress and cell damage. Adverse events caused by CBA-NSAIDs often exhibit dose and time dependence. In order to avoid adverse events caused by CBA-NSAIDs, it is necessary to provide detailed patient consultation and eliminate influencing factors. Moreover, constructive research studies on the organ-specific toxicity and mechanism of natural plant extracts in preventing and treating metabolic abnormalities of CBA-NSAIDs, will provide important value for warning and guidance for use of CBA-NSAIDs.
PB Taylor & Francis
YR 2024
FD 2024-07-08
LK https://hdl.handle.net/20.500.14352/124906
UL https://hdl.handle.net/20.500.14352/124906
LA eng
NO Liu Y, Yang C, Zhang J, Ihsan A, Ares I, Martínez M, Lopez-Torres B, Martínez-Larrañaga MR, Wang X, Anadón A, Martínez MA. Recent progress in adverse events of carboxylic acid non-steroidal anti-inflammatory drugs (CBA-NSAIDs) and their association with the metabolism: the consequences on mitochondrial dysfunction and oxidative stress, and prevention with natural plant extracts. Expert Opin Drug Metab Toxicol. 2024 Aug;20(8):765-785. doi: 10.1080/17425255.2024.2378885. Epub 2024 Jul 12. PMID: 38980754.
NO This work was supported by the National Natural Science Foundation of China(NSFC) (32072925) and Major Special Science and Technology Plan(202302AA310020) and Project Ref. PID 2020-115979RR-C33 from theMinisterio de Ciencia e Innovación, Spain (Project/AEI/10.13039/501100011033)
NO Ministerio de Ciencia e Innovación. (España)
NO National Natural Science Foundation of China
DS Docta Complutense
RD 9 abr 2026