RT Journal Article
T1 Porous microstructured surfaces with pH-triggered antibacterial properties
A1 Del Campo, Adolfo
A1 Echeverría, Coro
A1 San Martín, Miguel
A1 Cuervo Rodríguez, María Rocío
A1 Fernández-García, Marta
A1 Muñoz-Bonilla, Alexandra
AB New antibacterial films are designed with the capability to reversibly regulate their killing and repelling functions in response to variations in environmental pH. These systems consist of porous polystyrene surfaces as the main components and a copolymer bearing pH-sensitive thiazole and triazole groups as the minor components. These pH-sensitive groups, located on the surfaces, can be partially protonated at acidic pH levels, increasing the positive charge density of the surfaces and their antibacterial activity. Similarly, their bacterial adhesion and killing efficiencies in response to changes in pH are evaluated by analyzing the bacterial viability of Staphylococcus aureus bacteria on the surfaces under acidic and neutral pH values. It is demonstrated that after only 1 h of incubation with the bacterial suspension in acidic conditions, the surfaces killed the bacteria, while at pH = 7.4, some of the adhered bacteria are removed. Furthermore, the surface topography exerts an important role by intensifying this response.
PB Wiley
SN 1616-5187
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/101802
UL https://hdl.handle.net/20.500.14352/101802
LA eng
NO del Campo A, Echeverría C, San Martín M, Cuervo-Rodríguez R, Fernández-García M, Muñoz-Bonilla A. Porous Microstructured Surfaces with pH-Triggered Antibacterial Properties. Macromol Biosci. 2019 Jul 3; 19(8):1900127-35
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Commission
NO Consejo Superior de Investigaciones Científicas 
DS Docta Complutense
RD 28 abr 2025