RT Journal Article
T1 The maternal deprivation animal model revisited
A1 Marco López, Eva María
A1 Llorente, Ricardo
A1 López Gallardo, Meritxell
A1 Mela Rivas, Virginia
A1 Llorente Berzal, Álvaro
A1 Prada, Carmen
A1 Viveros, María Paz
AB Early life stress, in the form of MD (24 h at pnd 9), interferes with brain developmental trajectories modifying both behavioral and neurobiochemical parameters. MD has been reported to enhance neuroendocrine responses to stress, to affect emotional behavior and to impair cognitive function. More recently, changes in body weight gain, metabolic parameters and immunological responding have also been described. Present data give support to the fact that neuronal degeneration and/or astrocyte proliferation are present in specific brain regions, mainly hippocampus, prefrontal cortex and hypothalamus, which are particularly vulnerable to the effects of neonatal stress. The MD animal model arises as a valuable tool for the investigation of the brain processes occurring at the narrow time window comprised between pnd 9 and 10 that are critical for the establishment of brain circuitries critical for the regulation of behavior, metabolism and energy homeostasis. In the present review we will discuss three possible mechanisms that might be crucial for the effects of MD, namely, the rapid increase in glucocorticoids,the lack ofthe neonatal leptin surge, and the enhanced endocannabinoid signaling during the specific critical period of MD. A better understanding of the mechanisms underlying the detrimental consequences of MD is a concern for public health and may provide new insights into mental health prevention strategies and into novel therapeutic approaches in neuropsychiatry.
PB Elsevier
SN 0149-7634, ESSN: 1873-7528
YR 2015
FD 2015-04
LK https://hdl.handle.net/20.500.14352/23323
UL https://hdl.handle.net/20.500.14352/23323
LA eng
NO Ministerio de Economía y Competitividad (MINECO)
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud “Carlos III” (FIS), RETICS, Red de Trastornos Adictivos
NO Universidad Complutense de Madrid-Banco de Santander
DS Docta Complutense
RD 28 sept 2024