RT Journal Article
T1 BDNF Val66Met polymorphism and gamma band disruption in resting state brain functional connectivity: A magnetoencephalography study in cognitively intact older females
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Cuesta Prieto, Pablo
A1 López García, María Eugenia
A1 De Frutos Lucas, Jaisalmer
A1 Bruña Fernández, Ricardo
A1 Pereda de Pablo, Ernesto
A1 Barabash Bustelo, Ana
A1 Montejo, Pedro
A1 Montenegro Peña, María Mercedes
A1 Marcos Dolado, Alberto
A1 López-Higes Sánchez, Ramón
A1 Fernández Lucas, Alberto Amable
A1 Maestu Unturbe, Fernando
AB The pathophysiological processes undermining brain functioning decades before the onset of the clinical symptoms associated with dementia are still not well understood. Several heritability studies have reported that the Brain Derived Neurotrophic Factor (BDNF) Val66Met genetic polymorphism could contribute to the acceleration of cognitive decline in aging. This mutation may affect brain functional connectivity (FC), especially in those who are carriers of the BDNF Met allele. The aim of this work was to explore the influence of the BDNF Val66Met polymorphism in whole brain eyes-closed, resting-state magnetoencephalography (MEG) FC in a sample of 36 cognitively intact (CI) older females. All of them were ε3ε3 homozygotes for the apolipoprotein E (APOE) gene and were divided into two subgroups according to the presence of the Met allele: Val/Met group (n = 16) and Val/Val group (n = 20). They did not differ in age, years of education, Mini-Mental State Examination scores, or normalized hippocampal volumes. Our results showed reduced antero-posterior gamma band FC within the Val/Met genetic risk group, which may be caused by a GABAergic network impairment. Despite the lack of cognitive decline, these results might suggest a selective brain network vulnerability due to the carriage of the BDNF Met allele, which is linked to a potential progression to dementia. This neurophysiological signature, as tracked with MEG FC, indicates that age-related brain functioning changes could be mediated by the influence of particular genetic risk factors.
PB Frontiers
SN 1662-4548
YR 2018
FD 2018-10-02
LK https://hdl.handle.net/20.500.14352/100174
UL https://hdl.handle.net/20.500.14352/100174
LA eng
NO Rodríguez-Rojo IC, Cuesta P, López ME, de Frutos-Lucas J, Bruña R, Pereda E, Barabash A, Montejo P, Montenegro-Peña M, Marcos A, López-Higes R, Fernández A, Maestú F. BDNF Val66Met Polymorphism and Gamma Band Disruption in Resting State Brain Functional Connectivity: A Magnetoencephalography Study in Cognitively Intact Older Females. Front Neurosci. 2018 Oct 2;12:684. doi: 10.3389/fnins.2018.00684
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Ministerio de Educación, Cultura y Deporte (España)
NO Instituto de Salud Carlos III
NO Fundación La Caixa
NO Ministerio de Economía y Competitividad (España)
DS Docta Complutense
RD 26 feb 2026