RT Journal Article
T1 Dietary aflatoxin B1 (AFB1) reduces growth performance, impacting growth axis, metabolism, and tissue integrity in juvenile gilthead sea bream (Sparus aurata)
A1 Barany Ruiz, André
A1 Guilloto, María
A1 Cosano, Jesús
A1 de Boevre, Marthe
A1 Oliva, Milagrosa
A1 de Saeger, Sarah
A1 Fuentes, Juan
A1 Martínez-Rodríguez, Gonzalo
A1 Mancera, Juan Miguel
AB Mycotoxins are an increasing threat to all the related commodities from agriculture. Its occurrence is expected to increase due to climate change. Here, we examined the impacts of dietary toxicity of aflatoxin B1 (AFB1) in gilthead sea bream (Sparus aurata) at levels of 1 or 2 mg AFB1 kg􀀀 1 fish feed. Inclusion of AFB1 in the diet resulted in 80% inhibition of the total weight gain during the 85-day trial. Carbohydrate and lipid energetic metabolites, both in plasma and liver, were depleted. Moreover, the histopathological analysis revealed several tissue anomalies in the liver, kidney, and spleen. Furthermore, the relative expression of gene transcripts for growth regulation was affected by AFB1. Adenohypophyseal gh and hepatic igf1 were inversely correlated due to AFB1 effects. Relative expression levels of gene transcripts as stress indicators were increased at AFB1 highest doses, such as hypothalamic trh, crh, and crhbp, as well as star in head kidney. Interestingly circulating levels of cortisol were unaffected. Overall, our results showed that aquafeeds with AFB1 impaired growth, alter metabolism, tissue integrity, and transcriptomic responses. However, we did find AFB1 residue neither in the liver nor muscle.
SN 0044-8486
YR 2020
FD 2020
LK https://hdl.handle.net/20.500.14352/98099
UL https://hdl.handle.net/20.500.14352/98099
LA eng
NO Barany, A., et al. «Dietary Aflatoxin B1 (AFB1) Reduces Growth Performance, Impacting Growth Axis, Metabolism, and Tissue Integrity in Juvenile Gilthead Sea Bream (Sparus Aurata)». Aquaculture, vol. 533, febrero de 2021, p. 736189, https://doi.org/10.1016/j.aquaculture.2020.736189.
NO Ministerio de Economía y Competitividad (España)
NO Universidad de Cádiz
NO Portuguese Foundation for Science and Technology 
DS Docta Complutense
RD 9 abr 2025