RT Journal Article
T1 Daily Rhythms in the IGF-1 System in the Liver of Goldfish and Their Synchronization to Light/Dark Cycle and Feeding Time
A1 Alonso-Gómez, Aitana
A1 Madera Sánchez, Diego
A1 Alonso Gómez, Ángel Luis
A1 Valenciano González, Ana Isabel
A1 Delgado Saavedra, María Jesús
AB The relevance of the insulin-like growth factor-1 (IGF-1) system in several physiological processes is well-known in vertebrates, although little information about their temporal organization is available. This work aims to investigate the possible rhythmicity of the different components of the IGF-1 system (igf-1, the igf1ra and igf1rb receptors and the paralogs of its binding proteins IGFBP1 and IGFBP2) in the liver of goldfish. In addition, we also study the influence of two environmental cues, the light/dark cycle and feeding time, as zeitgebers. The hepatic igf-1 expression showed a significant daily rhythm with the acrophase prior to feeding time, which seems to be strongly dependent on both zeitgebers. Only igfbp1a-b and igfbp1b-b paralogs exhibited a robust daily rhythm of expression in the liver that persists in fish held under constant darkness or randomly fed. The hepatic expression of the two receptor subtypes did not show daily rhythms in any of the experimental conditions. Altogether these results point to the igf-1, igfbp1a-b, and igfbp1b-b as clock-controlled genes, supporting their role as putative rhythmic outputs of the hepatic oscillator, and highlight the relevance of mealtime as an external cue for the 24-h rhythmic expression of the IGF-1 system in fish.
PB MDPI
SN 2076-2615
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/108330
UL https://hdl.handle.net/20.500.14352/108330
LA eng
NO Alonso-Gómez, Aitana, et al. «Daily Rhythms in the IGF-1 System in the Liver of Goldfish and Their Synchronization to Light/Dark Cycle and Feeding Time». Animals, vol. 12, n.o 23, noviembre de 2022, p. 3371. DOI.org (Crossref), https://doi.org/10.3390/ani12233371.
NO Ministerio de Ciencia e Innovación (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 8 abr 2025