RT Journal Article T1 Aluminum Nanoholes for Optical Biosensing A1 Barrios, Carlos A1 Canalejas-Tejero, Víctor A1 Herranz, Sonia A1 Urraca Ruiz, Javier A1 Moreno Bondi, María Cruz A1 Avella-Oliver, Miquel A1 Maquieira, Ángel A1 Puchades, Rosa AB Sub-wavelength diameter holes in thin metal layers can exhibit remarkable optical features that make them highly suitable for (bio)sensing applications. Either as efficient light scattering centers for surface plasmon excitation or metal-clad optical waveguides, they are able to form strongly localized optical fields that can effectively interact with biomolecules and/or nanoparticles on the nanoscale. As the metal of choice, aluminum exhibits good optical and electrical properties, is easy to manufacture and process and, unlike gold and silver, its low cost makes it very promising for commercial applications. However, aluminum has been scarcely used for biosensing purposes due to corrosion and pitting issues. In this short review, we show our recent achievements on aluminum nanohole platforms for (bio)sensing. These include a method to circumvent aluminum degradation—which has been successfully applied to the demonstration of aluminum nanohole array (NHA) immunosensors based on both, glass and polycarbonate compact discs supports—the use of aluminum nanoholes operating as optical waveguides for synthesizing submicron-sized molecularly imprinted polymers by local photopolymerization, and a technique for fabricating transferable aluminum NHAs onto flexible pressure-sensitive adhesive tapes, which could facilitate the development of a wearable technology based on aluminum NHAs. PB MDPI SN 2079-6374 YR 2015 FD 2015-07-09 LK https://hdl.handle.net/20.500.14352/23868 UL https://hdl.handle.net/20.500.14352/23868 LA eng NO Ministerio de Economía y Competitividad (MINECO) DS Docta Complutense RD 9 abr 2025