RT Journal Article
T1 Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin
A1 Pérez García, Selene
A1 Carrión Caballo, Mar
A1 Gutiérrez Cañas, Irene
A1 Villanueva Romero, Raúl
A1 Castro Vázquez, David
A1 Martínez Mora, María Del Carmen
A1 González-Álvaro, Isidoro
A1 Blanco, Francisco J.
A1 Juarranz Moratilla, Yasmina
A1 Pérez Gomáriz, Rosa María
AB The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs.
PB MDPI
SN 2073-4409
YR 2019
FD 2019-12-22
LK https://hdl.handle.net/20.500.14352/6409
UL https://hdl.handle.net/20.500.14352/6409
LA eng
NO Instituto de Salud Carlos III (ISCIII) / FEDER
DS Docta Complutense
RD 26 abr 2025