RT Journal Article T1 Profile of Matrix-Remodeling Proteinases in Osteoarthritis: Impact of Fibronectin A1 Pérez García, Selene A1 Carrión Caballo, Mar A1 Gutiérrez Cañas, Irene A1 Villanueva Romero, Raúl A1 Castro Vázquez, David A1 Martínez Mora, María Del Carmen A1 González-Álvaro, Isidoro A1 Blanco, Francisco J. A1 Juarranz Moratilla, Yasmina A1 Pérez Gomáriz, Rosa María AB The extracellular matrix (ECM) is a complex and specialized three-dimensional macromolecular network, present in nearly all tissues, that also interacts with cell surface receptors on joint resident cells. Changes in the composition and physical properties of the ECM lead to the development of many diseases, including osteoarthritis (OA). OA is a chronic degenerative rheumatic disease characterized by a progressive loss of synovial joint function as a consequence of the degradation of articular cartilage, also associated with alterations in the synovial membrane and subchondral bone. During OA, ECM-degrading enzymes, including urokinase-type plasminogen activator (uPA), matrix metalloproteinases (MMPs), and a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTSs), cleave ECM components, such as fibronectin (Fn), generating fibronectin fragments (Fn-fs) with catabolic properties. In turn, Fn-fs promote activation of these proteinases, establishing a degradative and inflammatory feedback loop. Thus, the aim of this review is to update the contribution of ECM-degrading proteinases to the physiopathology of OA as well as their modulation by Fn-fs. PB MDPI SN 2073-4409 YR 2019 FD 2019-12-22 LK https://hdl.handle.net/20.500.14352/6409 UL https://hdl.handle.net/20.500.14352/6409 LA eng NO Instituto de Salud Carlos III (ISCIII) / FEDER DS Docta Complutense RD 5 abr 2025