%0 Journal Article
%A García Marchena, Nuria
%A Pizarro, Nieves
%A Martínez Huélamos, Miriam
%A Pavón Carrasco, Francisco Javier
%A Requena-Ocaña, Nerea
%A Araos, Pedro
%A Silva-Peña, Daniel
%A Suárez, Juan
%A Santín, Luis Javier
%A de la Torre, Rafael
%A Serrano, Antonia
%A Flores-López, María
%A Rodríguez De Fonseca, Fernando Antonio
%T Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients
%D 2020
%U https://hdl.handle.net/20.500.14352/95328
%X Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age/sex/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantifed and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulinlike growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment.
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