RT Journal Article
T1 Potential association of plasma lysophosphatidic acid (LPA) species with cognitive impairment in abstinent alcohol use disorders outpatients
A1 García Marchena, Nuria
A1 Pizarro, Nieves
A1 Martínez Huélamos, Miriam
A1 Pavón Carrasco, Francisco Javier
A1 Requena-Ocaña, Nerea
A1 Araos, Pedro
A1 Silva-Peña, Daniel
A1 Suárez, Juan
A1 Santín, Luis Javier
A1 de la Torre, Rafael
A1 Serrano, Antonia
A1 Flores-López, María
A1 Rodríguez De Fonseca, Fernando Antonio
AB Lysophosphatidic acid (LPA) species are bioactive lipids participating in neurodevelopmental processes. The aim was to investigate whether the relevant species of LPA were associated with clinical features of alcohol addiction. A total of 55 abstinent alcohol use disorder (AUD) patients were compared with 34 age/sex/body mass index-matched controls. Concentrations of total LPA and 16:0-LPA, 18:0-LPA, 18:1-LPA, 18:2-LPA and 20:4-LPA species were quantifed and correlated with neuroplasticity-associated growth factors including brain derived neurotrophic factor (BDNF), insulinlike growth factor-1 (IGF-1) and IGF-2, and neurotrophin-3 (NT-3). AUD patients showed dysexecutive syndrome (22.4%) and memory impairment (32.6%). Total LPA, 16:0-LPA, 18:0-LPA and 18:1-LPA concentrations, were decreased in the AUD group compared to control group. Total LPA, 16:0-LPA, 18:2-LPA and 20:4-LPA concentrations were decreased in men compared to women. Frontal lobe functions correlated with plasma LPA species. Alcohol-cognitive impairments could be related with the deregulation of the LPA species, especially in 16:0-LPA, 18:1-LPA and 20:4-LPA. Concentrations of BDNF correlated with total LPA, 18:2-LPA and 20:4-LPA species. The relation between LPA species and BDNF is interesting in plasticity and neurogenesis functions, their involvement in AUD might serve as a biomarker of cognitive impairment.
YR 2020
FD 2020-10-13
LK https://hdl.handle.net/20.500.14352/95328
UL https://hdl.handle.net/20.500.14352/95328
LA eng
DS Docta Complutense
RD 26 abr 2025