RT Journal Article T1 Comparative Clinical Study of Two Tooth Whitening Protocols. A Randomized Clinical Trial. Part 2. A1 Cantero-Gómez, María A1 Oteo Morilla, Carlos A1 Oteo Calatayud, María Dolores A1 Vicente-Sanchez, Jorge A1 Piedra-Cascón, Wenceslao AB This study clinically evaluated the efficacy of two different home tooth-whitening protocols to determine which one is more effective by applying the whitening gel every 48 hours or every 72 hours for 6 weeks. The differences in tooth sensitivity were also analyzed. A sample of 72 patients were randomly divided into four groups: In group A (n = 24), 16% carbamide peroxide (Pola Night, SDI Limited) was applied every 48 hours for 6 weeks; in group B (n = 24), 16% carbamide peroxide was applied every 72 hours for 6 weeks; in group C (control; n = 12), a placebo gel without peroxide (glycerin gel) was applied every 48 hours for 6 weeks; and in group D (control; n = 12), a placebo gel without peroxide (glycerin gel) was applied every 72 hours for 6 weeks. To compare the groups, color measurements were made using a spectrophotometer. For statistical analysis, ANOVA with Bonferroni test was used. The confidence interval (CI) was set at 95% (P ≤ .05). No statistically significant differences were found between applying 16% carbamide peroxide every 48 hours and every 72 hours for 6 weeks (P > .05). The study concluded that 16% carbamide peroxide was equally effective when applied using both protocols. PB Quintessence YR 2025 FD 2025-03-06 LK https://hdl.handle.net/20.500.14352/119701 UL https://hdl.handle.net/20.500.14352/119701 LA eng NO Cantero-Gómez M, Vicente-Sanchez J, Oteo-Calatayud MD, Piedra-Cascón W, Oteo-Morilla C. Comparative Clinical Study of Two Tooth-Whitening Protocols: A Randomized Clinical Trial. Part 2. Int J Periodontics Restorative Dent. 2025 Mar 6;45(2):199-207. doi: 10.11607/prd.7106 DS Docta Complutense RD 28 dic 2025