RT Journal Article
T1 Optical quality in vitro and in vivo of an extended depth-of-focus intraocular lens with isofocal design
A1 Fernández-Núñez, Sara
A1 Pérez-Sanz. Lidia, 
A1 Albarrán-Diego, César
A1 Garzón Jiménez, Nuria
A1 García Montero, María
A1 Gómez Pedrero, José Antonio
AB PurposeThe aim of this study is to compare optical quality results obtained in laboratory analysis (in vitro) versus clinical data (in vivo).MethodsThe optical quality of ISOPure intraocular lens was assessed both in vitro and in vivo using the modulation transfer function (MTF) for 3.0 and 4.5 mm pupil diameters. In vitro measurements were obtained using deflectometer NIMO TRF1504, while in vivo measurements were taken with OPD-Scan III in a set of patients implanted with this lens. Ray tracing techniques were used to determine the MTF and area under MTF curve (MTFa) from the measured wavefront for the isolated lens and for the whole eye.ResultsThe MTF of the isolated lens obtained under both in vitro and in vivo conditions showed comparable results for both pupil sizes. However, differences were found when comparing the MTF of the whole eye with the lens implanted versus the MTF measured in vitro for 4.5 mm pupil size. Also, the MTFa defocus curve was compared with the defocus curve measured in vivo.ConclusionThe defocus curve from the in vivo study aligns closely with the MTFa of the in vitro model, with a useful defocus range of 0.40D. Thus, it is possible to anticipate the visual results of the implanted isofocal lens by using measurements on an optical bench and conducting optical simulations.
PB Springer
SN 0721-832X
YR 2024
FD 2024-07-24
LK https://hdl.handle.net/20.500.14352/112660
UL https://hdl.handle.net/20.500.14352/112660
LA eng
NO Fernández-Núñez, S., Pérez-Sanz, L., Gómez-Pedrero, J.A. et al. Optical quality in vitro and in vivo of an extended depth-of-focus intraocular lens with isofocal design. Graefes Arch Clin Exp Ophthalmol (2024). https://doi.org/10.1007/s00417-024-06590-y
NO Spanish Government Agencia Estatal de Investigación and European Fund for Regional Development (PID2021-122486OA-I00)
NO Ministerio de Ciencia e Innovación (España)
NO European Fund for Regional Development
DS Docta Complutense
RD 7 abr 2025