RT Journal Article
T1 Funcionalizacion of Morin-Loaded PLGA Nanoparticles with Phenylalanine Dipeptide Targeting the Brain
A1 Alonso, Mario
A1 Barcia Hernández, Emilia María
A1 González Matilla, Juan Francisco
A1 Montejo, Consuelo
A1 García García, Luis
A1 Villa-Hermosilla, Mónica Carolina
A1 Negro Álvarez, María Sofía Elisa
A1 Fraguas Sánchez, Ana Isabel
A1 Fernández Carballido, Ana María
AB Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder, with its in cidence constantly increasing. To date, there is no cure for the disease, with a need for new and effective treatments. Morin hydrate (MH) is a naturally occurring flavonoid of the Moraceae family with antioxidant and anti-inflammatory properties; however, the blood–brain barrier (BBB) prevents this flavonoid from reaching the CNS when aiming to potentially treat AD. Seeking to use the LAT-1transporter present in the BBB, a nanoparticle (NPs) formulation loaded with MH and functional ized with phenylalanine-phenylalanine dipeptide was developed (NPphe-MH) and compared to non-functionalized NPs (NP-MH). In addition, two formulations were prepared using rhodamine B (Rh-B) as a fluorescent dye (NPphe-Rh and NP-Rh) to study their biodistribution and ability to cross the BBB. Functionalization of PLGA NPs resulted in high encapsulation efficiencies for both MH and Rh-B. Studies conducted in Wistar rats showed that the presence of phenylalanine dipeptide in the NPs modified their biodistribution profiles, making them more attractive for both liver and lungs, whereas non-functionalized NPs were predominantly distributed to the spleen. Formulation NPphe-Rh remained in the brain for at least 2 h after administration.
PB MPDI
SN 1999-4923
YR 2022
FD 2022-10-31
LK https://hdl.handle.net/20.500.14352/92431
UL https://hdl.handle.net/20.500.14352/92431
LA eng
NO Alonso, M.; Barcia, E.; González, J.-F.; Montejo, C.; García-García, L.; Villa-Hermosilla, M.-C.; Negro, S.; Fraguas-Sánchez, A.-I.; Fernández-Carballido, A. Functionalization of Morin-Loaded PLGA Nanoparticles with Phenylalanine Dipeptide Targeting the Brain. Pharmaceutics 2022, 14, 2348. https://doi.org/10.3390/pharmaceutics14112348
NO Complutense University of Madrid research group. “Formulation and Bioavailability of New Drugs”
DS Docta Complutense
RD 7 abr 2025