RT Journal Article
T1 Low – Dose CT: A useful and accesible tool for the early diagnosis of lung cancer in selected populations
A1 Callol Sánchez, Luis Miguel
A1 Roig, Francisco
A1 Cuevas, Alfredo
A1 Granda Orive, José Ignacio De
A1 Villegas, Francisco
A1 Jareño, Javier
A1 Arias, Eva
A1 Albiach, José Manuel
AB Objective: An evaluation is made of the effectiveness of low-dose computed tomography (LDCT) in diagnosing early stage lung cancer in the Autonomous Community of Madrid (Spain).Methods: The study comprised subjects over 50 years of age who were active smokers (or who had stopped smoking up to 6 months previously) who smoked more than 30 cigarettes daily for at least 15 years, or 20 cigarettes daily for 20 years, or more than 10 packs/year and in contact with asbestos at work. The study group was evaluated using LDCT. For all participants in whom LDCT showed no pathological findings, or in those cases classified as benign, a new LDCT scan was performed 2 years after the first. In case of doubt regarding the benign nature of the findings, an assessment algorithm was applied.Results: Among the initial 482 candidates in the study group, 466 LDCT scans were performed at baseline, revealing 9 extrapulmonary lesions and 114 pulmonary lesions in 98 subjects. The latter raised diagnostic doubts in 32 cases; of these, 15 were confirmed as benign by high resolution computed tomography (HRCT). In the remaining 17 cases, stage IAp adenocarcinoma was diagnosed at baseline (0.2%). With LDCT after 2 years, an additional four adenocarcinomas were diagnosed—–all in stage IAp (0.98%). The complete study, including prevalence cut-off and incidence calculation after 2 years, resulted in the diagnosis of five cancers (1.1%) and two false positive cases (28%).Conclusions: The use of low-dose computed tomography in risk groups is valid for the early diagnosis of bronchogenic cancer. Nevertheless, significant problems remain, particularly those associated with false positive interpretations. The results of randomized studies on lung cancer mortality such as the US NLST trial and the Dutch-Belgian NELSON trial have to be awaited before any conclusion regarding the effectiveness of LDCT screening can be drawn.
PB Elsevier
SN 0169-5002
YR 2006
FD 2006
LK https://hdl.handle.net/20.500.14352/97181
UL https://hdl.handle.net/20.500.14352/97181
LA eng
NO Callol Sánchez L, Roig F, Cuevas A, Granda JI, Villegas F, Jareño J, Arias E, Albiach JM. Low – Dose CT: A useful and accesible tool for the early diagnosis of lung cancer in selected populations. Lung Cancer. 2007; 56: 217 – 221 doi:10.1016/j.lungcan.2007.01.010
DS Docta Complutense
RD 4 abr 2025