RT Journal Article
T1 Immunomodulation of the Vaginal Ecosystem by Ligilactobacillus salivarius CECT 30632 Improves Pregnancy Rates among Women with Infertility of Unknown Origin or Habitual Abortions
A1 Fernández Álvarez, Leonides
A1 Castro Navarro, Irma
A1 Arroyo Rodríguez, Rebeca
A1 Alba Rubio, Claudio
A1 Beltrán, David
A1 Rodríguez Gómez, Juan Miguel
AB In this study, the probiotic potential of Ligilactobacillus salivarius CECT 30632 was assessed, including properties specifically related with gynecological targets. This strain displayed co-aggregative and antimicrobial activity against a wide spectrum of vaginal pathogens while being respectful with the growth of vaginal lactobacilli. The strain produced a high concentration of lactic acid and displayed α-amylase activity when assayed in vitro. It showed a noticeable survival rate after exposition to conditions similar to those present in the human digestive tract and was adhesive to both vaginal and intestinal cells. Subsequently, their capacity to increase pregnancy rates among women with habitual abortion or infertility of unknown origin was studied. Administration of L. salivarius CECT 30632 (~9 log10 CFU) daily for a maximum of six months to these women was safe and led to a successful pregnancy rate of 67.5% (80% and 55% for women with repetitive abortion and infertile women, respectively). Significant differences in Nugent score, vaginal pH, and vaginal concentrations of lactobacilli, TGF-β, and VEFG were observed when the samples collected before the intervention were compared with those collected after the treatment among those women who got pregnant. Therefore, this strain can modulate the vaginal ecosystem and lead to better fertility outcomes.
PB MDPI
YR 2023
FD 2023-01-11
LK https://hdl.handle.net/20.500.14352/103319
UL https://hdl.handle.net/20.500.14352/103319
LA eng
NO : Fernández, L.; Castro, I.; Arroyo, R.; Alba, C.; Beltrán, D.; Rodríguez, J.M. Immunomodulation of the Vaginal Ecosystem by Ligilactobacillus salivarius CECT 30632 Improves Pregnancy Rates among Women with Infertility of Unknown Origin or Habitual Abortions. Nutrients 2023, 15, 362. https:// doi.org/10.3390/nu15020362
NO Author Contributions: D.B., L.F. and J.M.R. designed and coordinated the study. D.B. recruited participants and recorded samples-associated metadata. I.C. and R.A. processed the samples and performed the microbiological and immunological analyses. C.A. executed statistical analysis. L.F. and J.M.R. drafted the manuscript. All authors have read and agreed to the published version of the manuscript.
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 28 abr 2025