RT Journal Article
T1 Fabrication of Organ-on-a-Chip using Microfluidics
A1 González Burgos, Elena María
A1 Serrano López, Dolores Remedios
A1 Susana Ying-Jin, 
A1 Iván Yuste, 
AB The use of microfluidic devices represents a significant advancement beyond conventional techniques in the development of innovative in vitro assays. Microfluidic chips are specialized devices that precisely control fluids at the microscale level through intricate microchannels, enabling the replication of physical and chemical conditions. When combined with tissue engineering, these chips have evolved into highly specialized tools known as Organ-on-a-Chip (OoC) devices, which can simulate the physiology and functionality of various human tissues and organs. OoC devices are cutting-edge technologies that integrate a biological component representing the target organ with a microfluidic component that mimics blood flow. This combination allows for the replication of biological structures with a more accurate representation of the in vivo physiological cellular microenvironment, which can be finely tuned by adjusting the flow rate and composition. As a result, novel microfluidic models for in vitro research can overcome the limitations of traditional 2D and 3D static cell cultures, enabling faster clinical translation and more precise predictions of the efficacy, safety, pharmacodynamics, and pharmacokinetics of new drugs. This review will discuss various techniques for fabricating OoCs and their applications in mimicking different physiological microenvironments.
PB Elsevier
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/120301
UL https://hdl.handle.net/20.500.14352/120301
LA eng
NO Ying-Jin S, Yuste I, González-Burgos E, Serrano DR. Fabrication of organ-on-a-chip using microfluidics. Bioprinting 2025;46:e00394. https://doi.org/10.1016/j.bprint.2025.e00394.
NO Ayudas de investigación ESCMID 2021 (16306).
NO Agencia Estatal de Investigación (España)
NO UCM
DS Docta Complutense
RD 14 jun 2025