RT Journal Article
T1 Colorectal cancer: from the genetic model to posttranscriptional regulation by noncoding RNAs
A1 Calle Espinosa, Jorge
A1 Olmo López, Nieves
A1 Turnay Abad, Francisco Javier
A1 Lizarbe Iracheta, María Antonia
A1 Fernández Lizarbe, Eva
A1 Fernández Lizarbe, Sara
A1 Robles, Miguel Ángel
AB Colorectal cancer is the third most common form of cancer in developed countries and, despite the improvements achieved in its treatment options, remains as one of the main causes of cancer-related death. In this review, we first focus on colorectal carcinogenesis and on the genetic and epigenetic alterations involved. In addition, noncoding RNAs have been shown to be important regulators of gene expression. We present a general overview of what is known about these molecules and their role and dysregulation in cancer, with a special focus on the biogenesis, characteristics, and function of microRNAs. These molecules are important regulators of carcinogenesis, progression, invasion, angiogenesis, and metastases in cancer, including colorectal cancer. For this reason, miRNAs can be used as potential biomarkers for diagnosis, prognosis, and efficacy of chemotherapeutic treatments, or even as therapeutic agents, or as targets by themselves. Thus, this review highlights the importance of miRNAs in the development, progression, diagnosis, and therapy of colorectal cancer and summarizes current therapeutic approaches for the treatment of colorectal cancer.
PB Hindawi Publishing Corporation
SN 2314-6133
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/18076
UL https://hdl.handle.net/20.500.14352/18076
LA eng
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Universidad Complutense de Madrid
NO Banco de Santander
DS Docta Complutense
RD 9 abr 2025