RT Journal Article
T1 An episodic burst of massive genomic rearrangements and the origin of non-marine annelids
A1 Vargas-Chávez, Carlos
A1 Benítez-Álvarez, Lisandra
A1 Martínez-Redondo, Gemma I.
A1 Álvarez-González, Lucía
A1 Salces-Ortiz, Judit
A1 Eleftheriadi, Klara
A1 Escudero, Nuria
A1 Guiglielmoni, Nadège
A1 Flot, Jean-François
A1 Novo Rodríguez, Marta
A1 Ruiz-Herrera, Aurora
A1 McLysaght, Aoife
A1 Fernández, Rosa
AB The genomic basis of cladogenesis and adaptive evolutionary change has intrigued biologists for decades. Here we show that the tectonics of genome evolution in clitellates, a clade composed of most freshwater and all terrestrial species of the phylum Annelida, is characterized by extensive genome-wide scrambling that resulted in a massive loss of macrosynteny between marine annelids and clitellates. These massive rearrangements included the formation of putative neocentromeres with newly acquired transposable elements and preceded a further period of genome-wide reshaping events, potentially triggered by the loss of genes involved in genome stability and homoeostasis of cell division. Notably, whereas these rearrangements broke short-range interactions observed between Hox genes in marine annelids, they were reformed as long-range interactions in clitellates. Our findings reveal extensive genomic reshaping in clitellates at both the linear (2D) and three-dimensional (3D) levels, suggesting that unlike in other animal lineages where synteny conservation constrains structural evolution, clitellates exhibit a remarkable tolerance for chromosomal rearrangements. Our study thus suggests that the genomic landscape of Clitellata resulted from a rare burst of genomic changes that ended a long period of stability that persists across large phylogenetic distances.
PB Springer
SN 2397-334X
YR 2025
FD 2025-06-18
LK https://hdl.handle.net/20.500.14352/123316
UL https://hdl.handle.net/20.500.14352/123316
LA eng
NO Vargas-Chávez, C., Benítez-Álvarez, L., Martínez-Redondo, G. I., Álvarez-González, L., Salces-Ortiz, J., Eleftheriadi, K., Escudero, N., Guiglielmoni, N., Flot, J.-F., Novo, M., Ruiz-Herrera, A., McLysaght, A., & Fernández, R. (2025). An episodic burst of massive genomic rearrangements and the origin of non-marine annelids. Nature Ecology & Evolution, 9(7), 1263-1279. https://doi.org/10.1038/s41559-025-02728-1
NO 948281/EC | EU Framework Programme for Research and Innovation H2020 | H2020 Priority Excellent Science | H2020 European Research Council (H2020 Excellent Science - European Research Council)
NO Consejo Europeo
DS Docta Complutense
RD 26 dic 2025