RT Journal Article
T1 Aging-associated oxidized albumin promotes cellular senescence and endothelial damage
A1 Luna, Carlos
A1 Alique, Matilde
A1 Navalmoral, Estefanía
A1 Noci, María Victoria
A1 Bohórquez Magro, Lourdes
A1 Carracedo Añón, Julia María
A1 Ramírez, Rafael
AB Increased levels of oxidized proteins with aging have been considered a cardiovascular risk factor. However, it is unclear whether oxidized albumin, which is the most abundant serum protein, induces endothelial damage. The results of this study indicated that with aging processes, the levels of oxidized proteins as well as endothelial microparticles release increased, a novel marker of endothelial damage. Among these, oxidized albumin seems to play a principal role. Through in vitro studies, endothelial cells cultured with oxidized albumin exhibited an increment of endothelial damage markers such as adhesion molecules and apoptosis levels. In addition, albumin oxidation increased the amount of endothelial microparticles that were released. Moreover, endothelial cells with increased oxidative stress undergo senescence. In addition, endothelial cells cultured with oxidized albumin shown a reduction in endothelial cell migration measured by wound healing. As a result, we provide the first evidence that oxidized albumin induces endothelial injury which then contributes to the increase of cardiovascular disease in the elderly subjects.
PB Dove Medical Press
SN 1176-9092
YR 2016
FD 2016-02
LK https://hdl.handle.net/20.500.14352/131354
UL https://hdl.handle.net/20.500.14352/131354
LA eng
NO Luna, C., Alique, M., Navalmoral, E., Noci, M.-V., Bohorquez-Magro, L., Carracedo, J., & Ramírez, R. (2016). Aging-associated oxidized albumin promotes cellular senescence and endothelial damage. Clinical Interventions in Aging, 11, 225-236. https://doi.org/10.2147/CIA.S91453
NO This work was supported by Plan Nacional Proyectos de Investigación en Salud of Instituto de Salud Carlos III (ISCIII) Fondos Feder European Grants (PI11/01536, PI12/01489, PI014/0041 and PI14/00806); Red de Investigación Renal (REDinREN; RD12/0021/002); Comunidad de Madrid (Fibroteam; S2010/BMD-2321); Junta de Andalucía Grants JA0797-2010, P010-CTS-6337, P11-CTS-7352.
NO Instituto de Salud Carlos III
NO European Commission
NO Comunidad de Madrid
NO Junta de Andalucía
DS Docta Complutense
RD 19 mar 2026