RT Journal Article
T1 DNA damage response and breast cancer development: Possible therapeutic applications of ATR, ATM, PARP, BRCA1 inhibition
A1 Mirza-Aghazadeh-Attari, Mohammad
A1 Ghazizadeh Darband, Saber
A1 Mojtaba Kaviani, 
A1 Safa, Amin
A1 Mihanfar, Ainaz
A1 Sadighparvar, Shirin
A1 Karimian, Ansar
A1 Alemi, Forough
A1 Majidinia, Maryam
A1 Yousefi, Bahman
A1 Recio Hoyas, María José
AB Breast cancer is the most common and significant cancers in females regarding the loss of life quality. Similar to other cancers, one of the etiologic factors in breast cancer is DNA damage. A plethora of molecules are responsible for sensing DNA damage and mediating actions which lead to DNA repair, senescence, cell cycle arrest and if damage is unbearable to apoptosis. In each of these, aberrations leading to unrepaired damage was resulted in uncontrolled proliferation and cancer. Another cellular function is autophagy defined as a process eliminating of unnecessary proteins in stress cases involved in pathogenesis of cancer. Knowing their role in cancer, scholars have tried to develop strategies in order to target DDR and autophagy. Further, the interactions of DDR and autophagy plus their regulatory role on each other have been focused simultaneously. The present review study has aimed to illustrate the importance of DDR and autophagy in breast cancer according to the related studies and uncover the relation between DDR and autophagy and its significance in breast cancer therapy.
PB ElSEVIER
SN 1568-7864
YR 2021
FD 2021-02
LK https://hdl.handle.net/20.500.14352/92846
UL https://hdl.handle.net/20.500.14352/92846
LA eng
NO Mirza-Aghazadeh-Attari M, Recio MJ, Darband SG, Kaviani M, Safa A, Mihanfar A, Sadighparvar S, Karimian A, Alemi F, Majidinia M, Yousefi B. DNA Repair (Amst). 2021 Feb;98:103032.
DS Docta Complutense
RD 21 ago 2024