RT Book, Section
T1 Structural and Functional Diversity of Microbial Metallothionein Genes
A1 Gutiérrez Fernández, Juan Carlos
A1 Francisco Martínez, Patricia de
A1 Amaro Torres, Francisco
A1 Díaz, Silvia
A1 Martín González, Ana María
A2 Das, Surajit
A2 Dash, Hirak Ranjan
AB In the present review, we discussed the concept of metallothionein (MT) and analyzed the structural and functional diversity of microbial MTs, grouping them into three main groups; bacteria, fungi, and protists. Structural diversity is analyzed based on the primary, secondary, and/or tertiary structure of the proteins. Their ability to bind different metals is also analyzed in each microbial group. An in silico and phylogenetic analysis of MT sequences from the main microbial groups has been carried out. The wide functional diversity of these proteins and the regulation of the MT gene expression are also discussed. The presence of several paralog genes in many microorganisms provides a coordinated and multiple response against different types of environmental stressors. Likewise, the main possible biotechnological applications of these proteins are explored, such as molecular tools to design biosensors for evaluating metal contamination and in metal bioremediation.
PB Elsevier
SN 978-0-12-814849-5
YR 2018
FD 2018-10-16
LK https://hdl.handle.net/20.500.14352/14004
UL https://hdl.handle.net/20.500.14352/14004
LA eng
DS Docta Complutense
RD 21 abr 2025