RT Journal Article
T1 Affective symptom dimensions in early-onset psychosis over time: a principal component factor analysis of the Young Mania Rating Scale and the Hamilton Depression Rating Scale
A1 Moreno Ruiz, María del Carmen
A1 Salazar de Pablo G, 
A1 Moreno Pardillo, Dolores María
A1 Gonzalez-Pinto A, 
A1 Paya B, 
A1 Castro-Fonieles J, 
A1 Baeza I, 
A1 Graell M, 
A1 Arango López, Celso
A1 Rapado Castro, Marta
AB Early-onset psychosis (EOP) is a complex disorder characterized by a wide range of symptoms, including affective symptoms. Our aim was to (1) examine the dimensional structure of affective symptoms in EOP, (2) evaluate the predominance of the clinical dimensions and (3) assess the progression of the clinical dimensions over a 2-year period. STROBE-compliant prospective principal component factor analysis of Young Mania Rating Scale (YMRS) and Hamilton Depression Rating Scale-21 (HDRS-21) at baseline, 6-months, 1-year and 2-year follow-up. We included 108 EOP individuals (mean age = 15.5 ± 1.8 years, 68.5% male). The factor analysis produced a four-factor model including the following dimensions: mania, depression/anxiety, sleep and psychosis. It explained 47.4% of the total variance at baseline, 60.6% of the total variance at 6-months follow-up, 54.5% of the total variance at 1-year follow-up and 49.5% of the total variance at 2-year follow-up. According to the variance explained, the mania factor was predominant at baseline (17.4%), 6-month follow-up (23.5%) and 2-year follow-up (26.1%), while the depression/anxiety factor was predominant at 1-year follow-up (23.1%). The mania factor was the most stable; 58.3% items that appeared in this factor (with a load > 0.4) at any time point appeared in the same factor at ≥ 3/4 time points. Affective symptoms are frequent and persistent in EOP. Mania seems to be the most predominant and stable affective dimension. However, depression and anxiety may gain predominance with time. A comprehensive evaluation of the dimensional structure and the progression of affective symptoms may offer clinical and therapeutic advantages.
PB Springer
SN 1435-165X
YR 2022
FD 2022
LK https://hdl.handle.net/20.500.14352/115867
UL https://hdl.handle.net/20.500.14352/115867
LA eng
NO Salazar de Pablo G, Moreno D, Gonzalez-Pinto A, Paya B, Castro-Fonieles J, Baeza I, Graell M, Arango C, Rapado-Castro M, Moreno C. Affective symptom dimensions in early-onset psychosis over time: a principal component factor analysis of the Young Mania Rating Scale and the Hamilton Depression Rating Scale. Eur Child Adolesc Psychiatry. 2022 Nov;31(11):1715-1728. doi: 10.1007/s00787-021-01815-5.
NO Spanish Ministry of Science, Innovation and Universities
NO Instituto de Salud Carlos III
NO European Regional Development Fund “A way of making Europe,”
NO Centro de Investigación Biomédica en Red Salud Mental, Madrid Regional Government
NO Fundación Alicia Koplowtiz
NO Fundación Mutua Madrileña
DS Docta Complutense
RD 6 abr 2025