RT Journal Article
T1 Characterizing patients with multiple chromosomal aberrations detected by FISH in chronic lymphocytic leukemia
A1 González-Gascón y Marín, Isabel
A1 Hernández Sánchez, María
A1 Rodríguez-Vicente, Ana Eugenia
A1 Puiggros, Anna
A1 Collado, Rosa
A1 Luño, Elisa
A1 González, Teresa
A1 Ruiz-Xivillé, Neus
A1 Ortega, Margarita
A1 Gimeno, Eva
A1 Muñoz, Carolina
A1 Infante, Maria Stefania
A1 Delgado, Julio
A1 Vargas, María Teresa
A1 González, Marcos
A1 Bosch, Francesc
A1 Espinet, Blanca
A1 Hernández-Rivas, Jesús María
A1 Hernández Rivas, José Ángel
AB We analyzed the features of chronic lymphocytic leukemia (CLL) with multiple abnormalities (MA) detected by FISH. A local database including 2095 CLL cases was used and 323 with MA (15.4%) were selected. MA was defined by the presence of two or more alterations (deletions of 13q14 (13q-), 11q22 (11q-), 17p13 (17p-) or trisomy 12 (+12)). The combination of 13q- with 11q- and 13q- with 17p-, accounted for 58.2% of the series, in contrast to 11q- with 17p- (3.7%). Patients carrying MA since diagnosis presented a short time to first therapy(TTFT) (27 months) and overall survival (OS) (76 months). The combinations including 17p- had a shorter OS (58 months) than the ones without 17p- (not reached, p = .002). Patients with a complex-FISH were the ones with worse OS (34 months). MA imply poor prognosis when they emerge at diagnosis, probably due to the high incidence of bad prognosis markers, which may be a reflection of a more complex karyotype.
PB Taylor & Francis
SN 1042-8194
YR 2017
FD 2017
LK https://hdl.handle.net/20.500.14352/93337
UL https://hdl.handle.net/20.500.14352/93337
LA eng
NO González-Gascón y Marín, I., Hernández-Sanchez, M., Rodríguez-Vicente, A. E., Puiggros, A., Collado, R., … Luño, E. (2017). Characterizing patients with multiple chromosomal aberrations detected by FISH in chronic lymphocytic leukemia. Leukemia & Lymphoma, 59(3), 633–642. https://doi.org/10.1080/10428194.2017.1349901
DS Docta Complutense
RD 6 abr 2025