RT Journal Article T1 Infuence of seton confguration, thickness, and laxity on patient comfort in chronic perianal fistula: a prospective comparative study A1 Barambio, J. A1 León Bretscher, Ana A1 Ramírez Bescós, María A1 Soto García, Paula A1 Gadea Uría, Paloma A1 Laloumet Garcimartín, Teresa A1 Viejo Martínez, Elena A1 Acedo Fernández De Pedro, Felipe A1 Ortega Domene, Patricia A1 Ruiz de la Hermosa, Alicia A1 De Fuenmayor Valera, María Luisa A1 Paseiro Crespo, Gloria Marta AB PurposeTo determine how seton configuration, thickness, and laxity influence patient comfort and clinical outcomes in the management of chronic perianal fistulas.MethodsA prospective single-center study was conducted involving 33 patients (53 setons). Both intraindividual paired (n = 20) and independent group analyses (n = 13) were performed. Setons were categorized by configuration (O-shaped vs. V-shaped), thickness (1.5 mm vs. 2.5 mm), and laxity (≤ 2 cm vs. > 2 cm from the anal verge). Patient-reported outcomes were assessed using structured questionnaires evaluating sitting discomfort, discharge, sexual impact, and fecal incontinence.ResultsO-shaped setons caused significantly less sitting discomfort than V-shaped ones (50.0% vs. 80.0%, p = 0.021). Excess laxity (> 2 cm) was associated with increased discharge (86.4% vs. 51.6%, p = 0.008), sexual impact (42.1% vs. 10.3%, p = 0.016), and fecal incontinence (66.7% vs. 10.0%, p = 0.041). Thicker setons (2.5 mm) showed a non-significant trend toward more pain (42.9% vs. 17.9%, p = 0.080).ConclusionSeton configuration and laxity significantly affect patient comfort. O-shaped setons and shorter laxity (≤ 2 cm) are preferable for reducing discomfort. These findings support evidence-based seton selection, although larger multicenter studies are needed to confirm these results. PB Springer Nature YR 2025 FD 2025-08-25 LK https://hdl.handle.net/20.500.14352/124346 UL https://hdl.handle.net/20.500.14352/124346 LA eng NO Barambio, J., Leon-Bretscher, A., Ramírez Bescos, M. et al. Influence of seton configuration, thickness, and laxity on patient comfort in chronic perianal fistula: a prospective comparative study. Int J Colorectal Dis 40, 187 (2025). https://doi.org/10.1007/s00384-025-04985-9 DS Docta Complutense RD 31 dic 2025