RT Journal Article
T1 Early prefrontal activation as a mechanism to prevent forgetting in the context of interference.
A1 Pacios García, Javier
A1 Gutiérrez, Ricardo
A1 Solesio, Elena
A1 Moratti, Stephan
A1 Ruiz Vargas, José María
A1 López Frutos, José María
A1 Lorenzo López, Laura
A1 Del Pozo, Francisco
A1 Maestu Unturbe, Fernando
AB Objective: Recent research has focused on interference resolution deficits as the main cause of short-term memory decreases in aging. To determine whether activation ofbrain compensatory mechanisms occur during the encoding process in older people. Moreover, two different levels of interference (distraction and interruption) were presented during the maintenance period to examine how they modulate brain activity profiles. Design: A delayed match-to-sample task with two experimental conditions: distraction and interruption. Participants: Twenty-seven young adults from Complutense University of Madrid and 20 healthy older adults from Complutense Elderly University of Madrid. Measurements: Magnetoencephalography scans were recorded during the execution of a working memory interference task. Brain activity sources from younger and older adults during the encoding stage were compared in each condition using minimum norm estimation analyses. Results: The elderly showed enhancement of prefrontal activity during early latencies of the encoding process in both conditions. In the distraction condition, enhanced activity was located in left ventrolateral prefrontal regions, whereas in the interruption condition, enhanced activity was observed in the right ventral prefrontal areas and anterior cingulate cortex. Conclusion: Increased recruitment of prefrontal regions in the elderly might be related to the processing depth of information, encoding of new information and semantic associations that are successfully recalled, and with interference resolution and preparatory control when the level of interference becomes higher. These prefrontal modulations during early latencies might reflect a higher top-down control of the encoding process in normal aging to prevent forgetting.
PB Elsevier
SN 1064-7481
YR 2013
FD 2013-06
LK https://hdl.handle.net/20.500.14352/119063
UL https://hdl.handle.net/20.500.14352/119063
LA eng
NO García-Pacios, J., Gutiérrez, R., Solesio, E., Moratti, S., Ruiz-Vargas, J. M., López-Frutos, J. M., Lorenzo-López, L., Del-Pozo, F., & Maestú, F. (2013). Early prefrontal activation as a mechanism to prevent forgetting in the context of interference. The American Journal of Geriatric Psychiatry, 21(6), 580-588. https://doi.org/10.1016/j.jagp.2012.12.021
DS Docta Complutense
RD 4 abr 2025