RT Journal Article
T1 Polyphenols and IUGR Pregnancies: Effects of Maternal Hydroxytyrosol Supplementation on Placental Gene Expression and Fetal Antioxidant Status, DNA-Methylation and Phenotype
A1 Garcia-Contreras, Consolación
A1 Vázquez Gómez, Marta
A1 Barbero, Alicia
A1 Pesantez, José
A1 Zinellu, Angelo
A1 Berlinguer, Fiammetta
A1 González Añover, Pedro
A1 Gonzalez, Jorge
A1 Encinas Cerezo, María Teresa
A1 Torres-Rovira, Laura
A1 Nuñez, Yolanda
A1 Ballesteros, Jaime
A1 Ayuso, Miriam
A1 Astiz, Susana
A1 Isabel Redondo, Beatriz
A1 Ovilo, Cristina
A1 González Bulnes, Antonio
AB The use of polyphenols is a promising strategy for preventing or alleviating intrauterine growth restriction (IUGR) because polyphenol supplementation increases plasma antioxidant capacity and improves oxidative stress at the feto-placental unit; which are recognized as main issues in IUGR. However, there is a scarcity of experimental data on both realistic benefits and potential hazards of polyphenol supplementation during gestation. Hence, we aimed to use a swine model of IUGR pregnancy to determine possible effects of maternal supplementation with polyphenols (hydroxytyrosol) on placental expression of genes involved in antioxidant homeostasis, vascularization and fetal growth and thus on antioxidant status, DNA-methylation and phenotypic traits (morphology and homeostasis) of the fetus. Hydroxytyrosol improves placental gene expression and fetal antioxidant status and glucose metabolism in a sex-dependent manner, in which males were favored in spite of developmental failures. Concomitantly, hydroxytyrosol prevented hypomethylation of DNA associated with oxidative stress. Finally, no major deleterious effects of hydroxytyrosol supplementation on constriction of the ductus arteriosus, a possible secondary effect of polyphenols during pregnancy, were found.
PB MDPI
SN 1422-0067
YR 2019
FD 2019-03-08
LK https://hdl.handle.net/20.500.14352/12514
UL https://hdl.handle.net/20.500.14352/12514
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
DS Docta Complutense
RD 22 abr 2025