RT Journal Article
T1 Obesity under the moonlight of c-MYC
A1 Nevzorova, Yulia
A1 Cubero Palero, Francisco Javier
AB The moonlighting protein c-Myc is a master regulator of multiple biological processes including cell proliferation, differentiation, angiogenesis, apoptosis and metabolism. It is constitutively and aberrantly expressed in more than 70% of human cancers. Overwhelming evidence suggests that c-Myc dysregulation is involved in several inflammatory, autoimmune, metabolic and other non-cancerous diseases. In this review, we addressed the role of c-Myc in obesity. Obesity is a systemic disease, accompanied by multi-organ dysfunction apart from white adipose tissue (WAT), such as the liver, the pancreas, and the intestine. c-Myc plays a big diversity of functions regulating cellular proliferation, the maturation of progenitor cells, fatty acids (FAs) metabolism, and extracellular matrix (ECM) remodeling. Moreover, c-Myc drives the expression of a wide range of metabolic genes, modulates the inflammatory response, induces insulin resistance (IR), and contributes to the regulation of intestinal dysbiosis. Altogether, c-Myc is an interesting diagnostic tool and/or therapeutic target in order to mitigate obesity and its consequences.
PB Frontiers Media
YR 2023
FD 2023
LK https://hdl.handle.net/20.500.14352/102302
UL https://hdl.handle.net/20.500.14352/102302
LA eng
NO Nevzorova YA, Cubero FJ. Obesity under the moonlight of c-MYC. Front Cell Dev Biol. 2023 Dec 5;11:1293218. doi: 10.3389/fcell.2023.1293218. PMID: 38116204; PMCID: PMC10728299.
DS Docta Complutense
RD 21 ago 2024